Circulating MicroRNA-122 for the Diagnosis of Hepatocellular Carcinoma: A Meta-Analysis

Table 1

Characteristics of the 13 included studies evaluating the diagnostic performance of miR-122 for HCC.

Author, year	Country	Number of HCC patients	Mean age (years) of HCC patients	Male (%) among HCC patients	Control population	Number of controls	Mean age (years) of controls	Male (%) among controls	Sample type	miRmeasurement method	QUADAS score
Xu, 2011 [12]	China	101	NR	77.2	HC	89	NR	76.4	Serum	RT-qPCR	9
Qi, 2011 [11]	China	70	49.0	78.6	HBV, HC	82	42.0	74.1	Serum	RT-qPCR	9
Luo, 2013 [13]	China	85	53.9	82.4	HBV, HC	85	50.8	81.2	Serum	RT-qPCR	8
Tan, 2014 [14]	China	135	53.6	83.0	LC, HBV	222	40.5	68.2	Serum	RT-qPCR	10
El-Garem, 2014 [16]	Egypt	30	60.3	83.3	LC	30	55.1	70.0	Serum	RT-qPCR	6
Hung, 2016 [17]	China	120	58.5	80.0	DN	30	60.3	80.0	Serum	RT-qPCR	11
Ali, 2017 [18]	Egypt	34	NR	76.5	HCV, HC	77	NR	71.6	Serum	RT-qPCR	8
Amr, 2017a [19]	Egypt	40	52	82.5	HCV, HC	60	50.0	83.0	Serum	RT-qPCR	9
Caviglia, 2017 [20]	Italy	33	63.0	87.9	LC	30	54.2	63.3	Serum	RT-qPCR	11
Trung, 2018 [22]	Vietnam	118	55.6	91.2	LC, HBV, HC	288	43.1	81.6	Serum	RT-qPCR	11
An, 2018 [21]	China	84	52.7	67.8	HC	84	51.5	59.7	Serum	RT-qPCR	8
Weis, 2019 [24]	Australia	20	58.3	75.0	LC	40	51.9	67.5	Serum	RT-qPCR	12
Dai, 2019 [23]	China	50	48.6	70.0	LC, HBV, HC	100	46.1	70.0	Serum	RT-qPCR	8

HCC: hepatocellular carcinoma; NR: not reported; HC: healthy controls; HBV: hepatitis B virus infection; HCV: hepatitis C virus infection; LC: liver cirrhosis; DN: dysplastic nodule; RT-qPCR: reverse transcription quantitative real-time polymerase chain reaction; QUADAS: Quality Assessment of Diagnostic Accuracy Studies.