The Neutrophil Percentage-to-Albumin Ratio Is Associated with All-Cause Mortality in Critically Ill Patients with Acute Kidney Injury

Table 2

HRs (95% CIs) for all-cause mortality across groups of neutrophil percentage-to-albumin ratios.

NAR	Nonadjusted		Model I		Model II
	HR (95% CIs)	value	HR (95% CIs)	value	HR (95% CIs)	value
30-day all-cause mortality
Tertiles
<22.1	1.0 (ref)		1.0 (ref)		1.0 (ref)
≥22.1, <28.1	1.35 (1.18, 1.54)	<0.01	1.27 (1.11, 1.45)	<0.01	1.20 (1.05, 1.38)	0.01
≥28.1	2.24 (1.99, 2.53)	<0.01	2.11 (1.86, 2.39)	<0.01	1.48 (1.30, 1.69)	<0.01
trend	<0.01		<0.01		<0.01
Quintiles
<19.6	1.0 (ref)		1.0 (ref)		1.0 (ref)
≥19.6, <23.2	1.04 (0.87, 1.24)	0.67	0.95 (0.79, 1.14)	0.58	0.97 (0.80, 1.17)	0.74
≥23.2, <26.7	1.29 (1.09, 1.53)	<0.01	1.18 (0.99, 1.40)	0.06	1.13 (0.94, 1.35)	0.19
≥26.7, <31.8	1.76 (1.49, 2.07)	<0.01	1.56 (1.32, 1.84)	<0.01	1.33 (1.12, 1.58)	<0.01
≥31.8	2.48 (2.13, 2.90)	<0.01	2.29 (1.96, 2.68)	<0.01	1.48 (1.25, 1.75)	<0.01
trend	<0.01		<0.01		<0.01
90-day all-cause mortality
Tertiles
<22.1	1.0 (ref)		1.0 (ref)		1.0 (ref)
≥22.1, <28.1	1.36 (1.22, 1.53)	<0.01	1.28 (1.14, 1.43)	<0.01	1.21 (1.07, 1.36)	<0.01
≥28.1	2.24 (2.02, 2.49)	<0.01	2.10 (1.89, 2.34)	<0.01	1.47 (1.31, 1.66)	<0.01
trend	<0.01		<0.01		<0.01
Quintiles
<19.6	1.0 (ref)		1.0 (ref)		1.0 (ref)
≥19.6, <23.2	1.09 (0.93, 1.27)	0.27	1.00 (0.85, 1.16)	0.96	1.04 (0.89, 1.23)	0.62
≥23.2, <26.7	1.31 (1.13, 1.52)	<0.01	1.19 (1.02, 1.38)	0.02	1.16 (0.99, 1.35)	0.06
≥26.7, <31.8	1.84 (1.60, 2.12)	<0.01	1.63 (1.41, 1.88)	<0.01	1.39 (1.20, 1.61)	<0.01
≥31.8	2.50 (2.18, 2.86)	<0.01	2.31 (2.01, 2.65)	<0.01	1.50 (1.30, 1.74)	<0.01
trend	<0.01		<0.01		<0.01
365-day all-cause mortality
Tertiles
<22.1	1.0 (ref)		1.0 (ref)		1.0 (ref)
≥22.1, <28.1	1.41 (1.28, 1.56)	<0.01	1.31 (1.18, 1.44)	<0.01	1.22 (1.10, 1.35)	<0.01
≥28.1	2.18 (1.99, 2.39)	<0.01	2.06 (1.88, 2.27)	<0.01	1.46 (1.32, 1.62)	<0.01
trend	<0.01		<0.01		<0.01
Quintiles
<19.6	1.0 (ref)		1.0 (ref)		1.0 (ref)
≥19.6, <23.2	1.11 (0.97, 1.27)	0.12	1.01 (0.88, 1.16)	0.87	1.06 (0.92, 1.22)	0.41
≥23.2, <26.7	1.34 (1.18, 1.52)	<0.01	1.20 (1.06, 1.37)	<0.01	1.17 (1.02, 1.33)	0.03
≥26.7, <31.8	1.83 (1.62, 2.07)	<0.01	1.61 (1.42, 1.82)	<0.01	1.36 (1.20, 1.55)	<0.01
≥31.8	2.40 (2.13, 2.70)	<0.01	2.25 (2.00, 2.54)	<0.01	1.49 (1.31, 1.70)	<0.01
trend	<0.01		<0.01		<0.01

HR: hazard ratio; CI: confidence interval. Models were derived from Cox proportional hazards regression models. Nonadjusted model, adjusted for none. Adjust I model, adjusted for age, ethnicity, and gender. Adjust II model, adjusted for age, ethnicity, gender, acute kidney injury stage, congestive heart failure, atrial fibrillation, liver disease, coronary artery disease, stroke, malignancy, respiratory failure, pneumonia, sodium, potassium, chloride, BUN, INR, APTT, platelet, WBC, hematocrit, creatinine, glucose, bicarbonate, vasopressor use, heart rate, systolic blood pressure, diastolic blood pressure, respiration rate, temperature, SPO₂, SOFA, SAPSII, and renal replacement therapy.