The Neutrophil Percentage-to-Albumin Ratio Is Associated with All-Cause Mortality in Critically Ill Patients with Acute Kidney Injury

Table 3

Subgroup analysis of the associations between the neutrophil percentage-to-albumin ratios and 30-day all-cause mortality.

	N	Neutrophil percentage-to-albumin ratios			for interaction
		<22.1	≥22.1, <28.1	≥28.1
CHF					0.92
No	6213	1.0 (ref)	1.28 (1.10, 1.48)	2.06 (1.81, 2.35)
Yes	1268	1.0 (ref)	1.31 (0.93, 1.84)	2.25 (1.61, 3.14)
AFIB					0.22
No	5505	1.0 (ref)	1.33 (1.13, 1.56)	2.22 (1.92, 2.58)
Yes	1976	1.0 (ref)	1.08 (0.86, 1.36)	1.80 (1.45, 2.23)
CAD					0.06
No	5853	1.0 (ref)	1.15 (0.99, 1.34)	1.90 (1.66, 2.18)
Yes	1628	1.0 (ref)	1.70 (1.27, 2.27)	2.67 (2.00, 3.55)
Stroke					0.22
No	6856	1.0 (ref)	1.29 (1.11, 1.49)	2.23 (1.95, 2.55)
Yes	625	1.0 (ref)	1.23 (0.88, 1.71)	1.65 (1.18, 2.32)
Malignancy					0.03
No	6073	1.0 (ref)	1.37 (1.17, 1.59)	2.21 (1.91, 2.55)
Yes	1408	1.0 (ref)	1.01 (0.77, 1.31)	1.61 (1.29, 2.02)
Liver disease					0.32
No	6680	1.0 (ref)	1.19 (1.03, 1.38)	2.01 (1.76, 2.30)
Yes	801	1.0 (ref)	1.39 (0.98, 1.97)	1.86 (1.35, 2.57)
Respiratory failure					<0.01
No	4302	1.0 (ref)	1.33 (1.09, 1.64)	2.48 (2.05, 3.01)
Yes	3179	1.0 (ref)	1.10 (0.92, 1.31)	1.49 (1.27, 1.75)
Pneumonia					0.05
No	5031	1.0 (ref)	1.38 (1.16, 1.64)	2.27 (1.94, 2.66)
Yes	2450	1.0 (ref)	1.04 (0.84, 1.28)	1.71 (1.41, 2.07)
AKI stage					0.02
Stage 1	1682	1.0 (ref)	1.11 (0.83, 1.48)	2.36 (1.82, 3.08)
Stage 2	1235	1.0 (ref)	1.08 (0.77, 1.51)	1.44 (1.05, 1.98)
Stage 3	4564	1.0 (ref)	1.35 (1.14, 1.59)	2.16 (1.85, 2.52)
WBC (109/L)					0.07
<7.6	2449	1.0 (ref)	1.19 (0.95, 1.49)	1.85 (1.50, 2.29)
≥7.6, <12.1	2528	1.0 (ref)	1.58 (1.23, 2.03)	2.53 (1.98, 3.22)
≥12.1	2502	1.0 (ref)	0.98 (0.78, 1.23)	1.61 (1.31, 1.99)
Sodium (mmol/L)					0.09
<134	2010	1.0 (ref)	1.05 (0.82, 1.35)	1.85 (1.48, 2.30)
≥134, <138	2333	1.0 (ref)	1.40 (1.11, 1.76)	1.87 (1.49, 2.34)
≥138	3136	1.0 (ref)	1.27 (1.02, 1.57)	2.34 (1.92, 2.85)
BUN (mg/dl)					0.28
<17	2295	1.0 (ref)	1.45 (1.09, 1.94)	1.90 (1.44, 2.52)
≥17, <34	2677	1.0 (ref)	1.19 (0.96, 1.48)	2.06 (1.68, 2.52)
≥34	2506	1.0 (ref)	1.02 (0.83, 1.26)	1.68 (1.39, 2.03)
INR					0.06
<1.2	2404	1.0 (ref)	1.36 (1.05, 1.76)	2.52 (1.96, 3.24)
≥1.2, <1.4	2176	1.0 (ref)	1.06 (0.81, 1.39)	1.59 (1.24, 2.05)
≥1.4	2639	1.0 (ref)	1.11 (0.91, 1.35)	1.62 (1.36, 1.93)
Potassium (mmol/L)					<0.01
<3.5	2415	1.0 (ref)	1.06 (0.83, 1.34)	1.52 (1.23, 1.88)
≥3.5, <4	2560	1.0 (ref)	1.23 (0.97, 1.56)	2.24 (1.80, 2.79)
≥4	2505	1.0 (ref)	1.40 (1.12, 1.75)	2.49 (2.02, 3.06)
APTT (seconds)					0.48
<26.7	2402	1.0 (ref)	1.29 (1.00, 1.67)	2.11 (1.63, 2.72)
≥26.7, <32.2	2404	1.0 (ref)	1.29 (1.01, 1.66)	1.91 (1.52, 2.41)
≥32.2	2405	1.0 (ref)	1.05 (0.85, 1.28)	1.65 (1.37, 1.98)
Platelet (109/L)					0.01
<139	2468	1.0 (ref)	1.10 (0.90, 1.35)	1.61 (1.35, 1.93)
≥139, <223	2492	1.0 (ref)	1.56 (1.23, 1.99)	2.39 (1.89, 3.03)
≥223	2518	1.0 (ref)	1.30 (1.00, 1.71)	2.47 (1.93, 3.15)
Hematocrit (%)					<0.01
<26.9	2470	1.0 (ref)	0.88 (0.69, 1.12)	1.60 (1.31, 1.95)
≥26.9, <32.3	2515	1.0 (ref)	1.29 (1.02, 1.63)	1.85 (1.48, 2.31)
≥32.3	2495	1.0 (ref)	1.57 (1.26, 1.96)	3.05 (2.44, 3.81)
Creatinine (mEq/L)					0.13
<0.9	2440	1.0 (ref)	1.59 (1.22, 2.09)	2.41 (1.88, 3.10)
≥0.9, <1.5	2490	1.0 (ref)	1.21 (0.96, 1.52)	2.03 (1.62, 2.53)
≥1.5	2549	1.0 (ref)	1.00 (0.82, 1.22)	1.67 (1.39, 2.00)
Bicarbonate (mg/dl)					<0.01
<18	2068	1.0 (ref)	1.00 (0.81, 1.24)	1.38 (1.14, 1.68)
≥18, <23	2775	1.0 (ref)	1.24 (0.99, 1.57)	2.08 (1.68, 2.58)
≥23	2636	1.0 (ref)	1.51 (1.18, 1.94)	2.72 (2.15, 3.45)
Glucose (mg/dl)					0.03
<119.9	2485	1.0 (ref)	1.43 (1.11, 1.84)	2.63 (2.10, 3.30)
≥119.9, <152.8	2484	1.0 (ref)	1.39 (1.10, 1.76)	2.16 (1.73, 2.71)
≥152.8	2485	1.0 (ref)	1.00 (0.82, 1.24)	1.62 (1.33, 1.96)
Chloride (mmol/L)					0.76
<99	2206	1.0 (ref)	1.17 (0.94, 1.47)	1.90 (1.53, 2.35)
≥99, <104	2370	1.0 (ref)	1.35 (1.07, 1.70)	2.33 (1.87, 2.89)
≥104	2903	1.0 (ref)	1.24 (0.98, 1.58)	2.12 (1.72, 2.63)
SBP (mmHg)					0.02
<108	2486	1.0 (ref)	0.99 (0.81, 1.21)	1.53 (1.28, 1.83)
≥108, <123	2485	1.0 (ref)	1.47 (1.15, 1.88)	2.21 (1.75, 2.79)
≥123	2486	1.0 (ref)	1.40 (1.08, 1.81)	2.40 (1.87, 3.07)
DBP (mmHg)					0.36
<55	2485	1.0 (ref)	1.19 (0.96, 1.48)	2.01 (1.65, 2.44)
≥55, <64	2486	1.0 (ref)	1.07 (0.85, 1.35)	1.81 (1.47, 2.23)
≥64	2486	1.0 (ref)	1.50 (1.18, 1.92)	2.22 (1.74, 2.83)
Heart rate (beats/minute)					0.02
<80	2487	1.0 (ref)	1.52 (1.20, 1.92)	2.63 (2.10, 3.31)
≥80, <96	2488	1.0 (ref)	1.26 (0.99, 1.61)	2.04 (1.63, 2.55)
≥96	2490	1.0 (ref)	1.00 (0.80, 1.24)	1.54 (1.27, 1.86)
Respiratory rate (beats/minute)					<0.01
<18	2483	1.0 (ref)	1.72 (1.31, 2.25)	2.62 (2.03, 3.38)
≥18, <22	2482	1.0 (ref)	1.28 (1.01, 1.64)	2.45 (1.96, 3.06)
≥22	2485	1.0 (ref)	0.93 (0.76, 1.13)	1.40 (1.17, 1.67)
Temperature (°C)					0.04
<36.5	2464	1.0 (ref)	1.47 (1.19, 1.83)	2.37 (1.94, 2.88)
≥36.5, <37.1	2465	1.0 (ref)	1.28 (1.00, 1.66)	2.37 (1.87, 2.99)
≥37.1	2470	1.0 (ref)	1.04 (0.83, 1.32)	1.55 (1.25, 1.93)
SPO2 (%)					0.07
<96.5	2478	1.0 (ref)	1.06 (0.86, 1.30)	2.01 (1.67, 2.43)
≥96.5, <98.3	2491	1.0 (ref)	1.17 (0.91, 1.51)	2.05 (1.63, 2.57)
≥98.3	2485	1.0 (ref)	1.61 (1.26, 2.05)	2.28 (1.81, 2.87)
SOFA score					<0.01
<4	2295	1.0 (ref)	1.49 (1.09, 2.05)	2.52 (1.83, 3.45)
≥4, <7	2581	1.0 (ref)	1.24 (0.96, 1.59)	2.01 (1.59, 2.54)
≥7	2605	1.0 (ref)	1.02 (0.85, 1.22)	1.34 (1.14, 1.58)
SAPSII score					<0.01
<34	2375	1.0 (ref)	1.42 (0.93, 2.16)	2.93 (1.97, 4.36)
≥34, <47	2607	1.0 (ref)	1.36 (1.06, 1.74)	1.98 (1.56, 2.52)
≥47	2499	1.0 (ref)	1.02 (0.86, 1.21)	1.27 (1.09, 1.48)
Vasopressor use					<0.01
No	4472	1.0 (ref)	1.48 (1.20, 1.83)	2.66 (2.18, 3.25)
Yes	3009	1.0 (ref)	1.03 (0.86, 1.22)	1.40 (1.20, 1.64)
Renal replacement therapy					<0.01
No	6692	1.0 (ref)	1.24 (1.07, 1.43)	2.17 (1.90, 2.48)
Yes	789	1.0 (ref)	1.16 (0.83, 1.63)	1.34 (0.97, 1.84)

CHF: congestive heart failure; AFIB: atrial fibrillation; CAD: coronary artery disease; AKI: acute kidney injury; WBC: white blood cell; BUN: blood urea nitrogen; INR: international normalized ratio; APTT: activated partial thromboplastin time; SBP: systolic blood pressure; DBP: diastolic blood pressure; SOFA: sequential organ failure assessment; SAPSII: simplified acute physiology score II.