Sinapic Acid Promotes Browning of 3T3-L1 Adipocytes via p38 MAPK/CREB Pathway

Figure 4

p38 MAPK and CREB mediate the browning effect of sinapic acid in 3T3-L1 cells. (a) 3T3-L1 adipocytes were treated with sinapic acid at the indicated concentrations. The levels of p38 MAPK, CREB, AKT, and AMPK proteins were measured by western blotting. (b, c) Cells exposed to 20 μM sinapic acid were treated with the p38 MAPK inhibitor SB 203580 (b) and the CREB inhibitor 666-15 (c). The level of mitochondrial biogenesis-related genes and thermogenic genes in 3T3-L1 adipocytes were analyzed by western blot analysis.

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