Association between Body Mass Index and Short-Term Clinical Outcomes in Critically Ill Patients with Sepsis: A Real-World Study
Table 1
Characteristics of participants.
Parameters
All patients
Underweight (<18.5 kg/m2)
Normal (≥18.5, <25 kg/m2)
Overweight (≥25, <30 kg/m2)
Obese (≥30 kg/m2)
value
7967
325
2513
2465
2664
Age (years)
<0.001
Sex, n(%)
<0.001
Male
4402 (55.25%)
155 (47.69%)
1363 (54.24%)
1486 (60.28%)
1398 (52.48%)
Female
3565 (44.75%)
170 (52.31%)
1150 (45.76%)
979 (39.72%)
1266 (47.52%)
SOFA
5.00 (3.00-8.00)
4.00 (3.00-8.00)
5.00 (3.00-8.00)
6.00 (4.00-8.00)
6.00 (4.00-8.00)
<0.001
Elixhauser Comorbidity Index (SID30)
19.00 (10.00-29.00)
21.00 (12.00-31.00)
20.00 (11.00-30.00)
20.00 (11.00-29.00)
18.00 (9.00-28.00)
<0.001
Mechanical ventilation on the first day
4918 (61.73%)
175 (53.85%)
1493 (59.41%)
1511 (61.30%)
1739 (65.28%)
<0.001
Renal replacement therapy on the first day
536 (6.73%)
18 (5.54%)
152 (6.05%)
169 (6.86%)
197 (7.39%)
0.209
Length of hospital stay (days)
14.46 (8.15-24.69)
11.86 (7.07-21.86)
13.66 (7.73-23.58)
14.64 (8.32-24.99)
15.51 (8.91-25.39)
<0.001
Length of ICU stay (days)
5.85 (2.80-12.04)
4.38 (2.22-8.99)
5.23 (2.53-11.16)
5.86 (2.86-11.92)
6.50 (3.05-13.30)
<0.001
Hospital mortality, (%)
1723 (21.63%)
77 (23.69%)
603 (24.00%)
533 (21.62%)
510 (19.14%)
<0.001
ICU mortality, (%)
1254 (15.74%)
53 (16.31%)
436 (17.35%)
397 (16.11%)
368 (13.81%)
0.005
28-day mortality, (%)
1667 (20.92%)
89 (27.38%)
597 (23.76%)
515 (20.89%)
466 (17.49%)
<0.001
Comorbidities, (%)
Congestive heart failure
3194 (40.09%)
107 (32.92%)
972 (38.68%)
979 (39.72%)
1136 (42.64%)
<0.001
Cardiac arrhythmias
3047 (38.25%)
85 (26.15%)
989 (39.36%)
936 (37.97%)
1037 (38.93%)
<0.001
Valvular disease
1317 (16.53%)
49 (15.08%)
447 (17.79%)
403 (16.35%)
418 (15.69%)
0.187
Peripheral vascular disease
1133 (14.22%)
57 (17.54%)
387 (15.40%)
365 (14.81%)
324 (12.16%)
0.001
Hypertension
4326 (54.30%)
129 (39.69%)
1286 (51.17%)
1332 (54.04%)
1579 (59.27%)
<0.001
Other neurological disease
1130 (14.18%)
62 (19.08%)
387 (15.40%)
369 (14.97%)
312 (11.71%)
<0.001
Chronic pulmonary disease
1913 (24.01%)
102 (31.38%)
602 (23.96%)
529 (21.46%)
680 (25.53%)
<0.001
Liver disease
987 (12.39%)
39 (12.00%)
276 (10.98%)
310 (12.58%)
362 (13.59%)
0.041
Renal failure
1806 (22.67%)
67 (20.62%)
523 (20.81%)
588 (23.85%)
628 (23.57%)
0.030
AIDS
104 (1.31%)
7 (2.15%)
56 (2.23%)
28 (1.14%)
13 (0.49%)
<0.001
Lymphoma
216 (2.71%)
12 (3.69%)
68 (2.71%)
72 (2.92%)
64 (2.40%)
0.464
Metastatic cancer
436 (5.47%)
24 (7.38%)
172 (6.84%)
151 (6.13%)
89 (3.34%)
<0.001
Solid tumor
386 (4.84%)
29 (8.92%)
129 (5.13%)
112 (4.54%)
116 (4.35%)
0.003
Diabetes
2468 (30.98%)
45 (13.85%)
553 (22.01%)
713 (28.92%)
1157 (43.43%)
<0.001
Fluid and electrolyte disorders
3876 (48.65%)
163 (50.15%)
1221 (48.59%)
1201 (48.72%)
1291 (48.46%)
0.952
Alcohol abuse
625 (7.84%)
14 (4.31%)
196 (7.80%)
200 (8.11%)
215 (8.07%)
0.108
Drug abuse
291 (3.65%)
9 (2.77%)
117 (4.66%)
84 (3.41%)
81 (3.04%)
0.011
Depression
791 (9.93%)
35 (10.77%)
211 (8.40%)
245 (9.94%)
300 (11.26%)
0.007
Data are expressed as median (Q1–Q3) or (SD) for continuous variables and as numbers and percentages for categorical variables. Chi-square tests (for categorical variables) and one-way analysis of variance (for continuous variables) were used to compare differences in patient characteristics between groups. Abbreviations: ICU—intensive care unit; SOFA—sequential organ failure assessment; AIDS—acquired immune deficiency syndrome.
