Association between Body Mass Index and Short-Term Clinical Outcomes in Critically Ill Patients with Sepsis: A Real-World Study

Table 2

Associations between BMI categories and clinical outcomes.

(a)

28-day mortality	Groups	HR (95% CI)	value
Crude	Normal	1.0	—
	Underweight	1.17 (0.94-1.47)	0.1609
	Overweight	0.87 (0.77-0.98)	0.0175
	Obese	0.71 (0.63-0.80)	<0.0001
Model I	Normal	1.0	—
	Underweight	1.20 (0.96-1.50)	0.1117
	Overweight	0.86 (0.76-0.97)	0.0130
	Obese	0.75 (0.66-0.84)	<0.0001
Model II	Normal	1.0	—
	Underweight	1.16 (0.93-1.46)	0.1845
	Overweight	0.87 (0.78-0.98)	0.0263
	Obese	0.78 (0.69-0.88)	0.0001

(b)

ICU mortality	Groups	OR (95% CI)	value
Crude	Normal	1.0	—
	Underweight	0.93 (0.68-1.27)	0.6398
	Overweight	0.91 (0.79-1.06)	0.2397
	Obese	0.76 (0.66-0.89)	0.0005
Model I	Normal	1.0	—
	Underweight	1.01 (0.73-1.41)	0.9365
	Overweight	0.86 (0.73-1.01)	0.0578
	Obese	0.73 (0.62-0.85)	0.0001
Model II	Normal	1.0	—
	Underweight	0.97 (0.70-1.36)	0.8721
	Overweight	0.87 (0.74-1.02)	0.0902
	Obese	0.77 (0.65-0.91)	0.0023

Cox regression models and logistic regression models were used to examine the independent role of BMI category in relation to 28-day and ICU mortality. Model I was adjusted by age, sex, SOFA, Elixhauser Comorbidity Index (SID30), mechanical ventilation on the first day, and renal replacement therapy on the first day. Model II was adjusted by age, sex, SOFA, mechanical ventilation on the first day, renal replacement therapy on the first day, congestive heart failure, cardiac arrhythmias, valvular disease, peripheral vascular disease, hypertension, other neurological diseases, chronic pulmonary disease, liver disease, renal failure, AIDS, lymphoma, metastatic cancer, solid tumor, diabetes, fluid and electrolyte disorders, alcohol abuse, drug abuse, and depression. Abbreviations: HR—hazard ratio; OR—odds ratio; CI—confidence interval; SOFA—sequential organ failure assessment; AIDS—acquired immune deficiency syndrome.