Association between Body Mass Index and Short-Term Clinical Outcomes in Critically Ill Patients with Sepsis: A Real-World Study
Table 4
Effect size of new BMI categories on 28-day mortality rate in prespecified and exploratory subgroups in each subgroup.
Outcomes: 28-year mortality
Crude
Adjusted model
BMI (kg/m2)
HR (95% CI)
value
HR (95% CI)
value
interaction
Age (years): <65
0.6539
≥18.5, <25
1.0
—
1.0
—
<18.5
1.09 (0.71-1.67)
0.6932
1.20 (0.78-1.85)
0.4028
≥25, <30
0.88 (0.71-1.10)
0.2646
0.87 (0.69-1.08)
0.2014
≥30, <40
0.82 (0.65-1.03)
0.0857
0.78 (0.62-0.99)
0.0410
≥40
0.76 (0.56-1.03)
0.0773
0.91 (0.66-1.25)
0.5455
Age (years): ≥65
≥18.5, <25
1.0
—
1.0
—
<18.5
1.20 (0.92-1.55)
0.1764
1.16 (0.89-1.51) 0.87
0.2775
≥25, <30
0.87 (0.75-1.00)
0.0456
(0.75-1.00)
0.0457
≥30, <40
0.67 (0.57-0.78)
<0.0001
0.67 (0.56-0.79)
<0.0001
≥40
0.89 (0.68-1.17)
0.4194
0.85 (0.64-1.13)
0.2604
Sex: male
0.0071
≥18.5, <25
1.0
—
1.0
—
<18.5
0.92 (0.66-1.28)
0.6098
0.90 (0.64-1.27)
0.5562
≥25, <30
0.77 (0.66-0.89)
0.0007
0.74 (0.63-0.86)
0.0001
≥30, <40
0.59 (0.50-0.71)
<0.0001
0.63 (0.53-0.76)
<0.0001
≥40
0.69 (0.52-0.92)
0.0119
0.86 (0.64-1.16)
0.3333
Sex: female
≥18.5, <25
1.0
—
1.0
—
<18.5
1.47 (1.09-1.99)
0.0123
1.47 (1.09-2.00)
0.0128
≥25, <30
1.02 (0.85-1.23)
0.8039
1.13 (0.94-1.35)
0.2001
≥30, <40
0.84 (0.69-1.02)
0.0715
0.92 (0.76-1.13)
0.4268
≥40
0.75 (0.57-0.99)
0.0438
1.05 (0.79-1.41)
0.7243
Mechanical ventilation on first day: no
0.2258
≥18.5, <25
1.0
—
1.0
—
<18.5
0.97 (0.68-1.39)
0.8722
1.01 (0.70-1.46) 0.92
0.9497
≥25, <30
0.89 (0.73-1.07)
0.2096
(0.76-1.12)
0.3921
≥30, <40
0.63 (0.50-0.79)
<0.0001
0.66 (0.52-0.83)
0.0005
≥40
0.83 (0.59-1.18)
0.3042
1.08 (0.76-1.55)
0.6638
Mechanical ventilation on first day: yes
≥18.5, <25
1.0
—
1.0
—
<18.5
1.33 (1.00-1.77)
0.0465
1.27 (0.95-1.69)
0.1054
≥25, <30
0.85 (0.74-0.99)
0.0391
0.85 (0.73-0.99)
0.0390
≥30, <40
0.72 (0.62-0.85)
<0.0001
0.79 (0.67-0.93)
0.0045
≥40
0.65 (0.51-0.83)
0.0006
0.84 (0.65-1.08)
0.1728
Renal replacement therapy on first day: no
0.2344
≥18.5, <25
1.0
—
1.0
—
<18.5
1.20 (0.96-1.51)
0.1153
1.22 (0.97-1.54)
0.0876
≥25, <30
0.86 (0.76-0.97)
0.0144
0.88 (0.78-1.00)
0.0460
≥30, <40
0.70 (0.61-0.80)
<0.00010.0035
0.76 (0.66-0.88)
0.0002
≥40
0.73 (0.59-0.90)
0.97 (0.78-1.20)
0.7656
Renal replacement therapy on first day: yes
≥18.5, <25
1.0
—
1.0
—
<18.5
0.71 (0.28-1.78)
0.4650
0.74 (0.28-1.93)
0.5383
≥25, <30
0.93 (0.64-1.36)
0.7092
0.81 (0.55-1.21)
0.3076
≥30, <40
0.61 (0.40-0.94)
0.0258
0.63 (0.40-0.99)
0.0433
≥40
0.45 (0.22-0.92)
0.0284
0.50 (0.24-1.05)
0.0678
SOFA: <5
0.7859
≥18.5, <25
1.0
—
1.0
—
<18.5
1.22 (0.85-1.75)
0.2771
1.14 (0.79-1.64)
0.4928
≥25, <30
0.81 (0.65-1.02)
0.0693
0.87 (0.70-1.09)
0.2383
≥30, <40
0.54 (0.42-0.71)
<0.0001
0.68 (0.52-0.90)
0.0066
≥40
0.53 (0.34-0.83)
0.0055
0.85 (0.53-1.36)
0.5003
SOFA: ≥5, <10
≥18.5, <25
1.0
—
1.0
—
<18.5
1.29 (0.92-1.82)
0.1359
1.18 (0.84-1.66)
0.3522
≥25, <30
0.79 (0.66-0.95)
0.0101
0.81 (0.67-0.97)
0.0204
≥30, <40
0.68 (0.56-0.82)
<0.0001
0.75 (0.61-0.92)
0.0049
≥40
0.65 (0.48-0.87)
0.0043
0.91 (0.67-1.25)
0.5768
SOFA: ≥10, <15
≥18.5, <25
1.0
—
1.0
—
<18.5
1.19 (0.70-2.04)
0.5200
1.19 (0.69-2.05)
0.5380
≥25, <30
0.89 (0.69-1.14)
0.3466
0.93 (0.72-1.20)
0.5749
≥30, <40
0.76 (0.58-1.00)
0.0484
0.80 (0.61-1.06)
0.1191
≥40
0.77 (0.53-1.13)
0.1849
0.95 (0.64-1.41)
0.7995
SOFA: ≥15
≥18.5, <25
1.0
—
1.0
—
<18.5
0.91 (0.12-6.73)
0.9286
1.45 (0.16-13.38)
0.7433
≥25, <30
1.17 (0.69-1.96)
0.5608
1.24 (0.67-2.30)
0.4842
≥30, <40
0.71 (0.40-1.27)
0.2480
0.67 (0.36-1.26)
0.2124
≥40
0.93 (0.42-2.05)
0.8544
0.83 (0.33-2.06)
0.6863
Interaction tests and stratified analyses explored the relationship between the new BMI categories across subgroup variables. Note: adjusted for age, sex, SOFA, mechanical ventilation on the first day, renal replacement therapy on the first day, congestive heart failure, cardiac arrhythmias, valvular disease, peripheral vascular disease, hypertension, other neurological diseases, chronic pulmonary disease, liver disease, renal failure, AIDS, lymphoma, metastatic cancer, solid tumor, diabetes, fluid and electrolyte disorders, alcohol abuse, drug abuse, and depression except for the subgroup variable. Abbreviations: BMI—body mass index; HR—hazard ratio; CI—confidence interval.
