Safety and Prognostic Impacts of Ovarian Preservation during Radical Hysterectomy for Early-Stage Adenocarcinoma and Adenosquamous Cervical Cancer
Table 1
Characteristic comparison between patients aged <50 years with or without ovarian preservation.
Characteristics
Total ()
OP ()
Non-OP ()
value
Age
41 (36, 45)
38 (35, 42)
45 (41, 47)
<0.001
FIGO stage
0.033
IA2
25 (12.8)
8 (7.4)a
17 (19.3)
71 (36.2)
44 (40.7)b
27 (30.7)
100 (51.0)
56 (51.9)a,b
44 (50.0)
Histology
0.550
Adenocarcinoma
167 (85.2)
94 (87.0)
73 (83.0)
Adenosquamous
29 (14.8)
14 (13.0)
15 (17.0)
LVSI
0.566
No
169 (86.2)
95 (88.0)
74 (84.1)
Yes
27 (13.8)
13 (12.0)
14 (15.9)
Parametrial invasion
0.349
No
186 (94.9)
104 (96.3)
82 (93.2)
Yes
10 (5.1)
4 (3.7)
6 (6.8)
LN metastasis
0.703
No
189 (96.4)
105 (97.2)
84 (95.5)
Yes
7 (3.6)
3 (2.8)
4 (4.5)
Vaginal margin involvement
1.000
No
192 (98.0)
106 (98.1)
86 (96.7)
Yes
4 (2.0)
2 (1.9)
2 (2.3)
DSI
1.000
No
154 (78.6)
85 (78.7)
69 (78.4)
Yes
42 (21.4)
23 (21.3)
19 (21.6)
Type of surgery
0.254
Open
193 (98.5)
105 (97.2)
88 (100)
Laparoscopic
3 (1.5)
3 (2.8)
0 (0)
Adjuvant treatment
0.092
No
171 (87.2)
99 (91.7)
72 (81.8)
RT
19 (9.7)
6 (5.6)
13 (14.8)
CCRT
6 (3.1)
3 (2.8)
3 (3.4)
Year of treatment
0.008
1987-1999
56 (28.6)
22 (20.4)
34 (38.6)
2000-2017
140 (71.4)
86 (79.6)
54 (61.4)
Postoperative HRT
<0.001
No
143 (73.0)
93 (86.1)
50 (56.8)
Yes
27 (13.8)
6 (5.6)
21 (23.9)
Missing
26 (13.2)
9 (8.3)
17 (19.3)
Recurrence
0.712
No
173 (88.3)
94 (87.0)
79 (89.8)
Yes
23 (11.7)
14 (13.0)
9 (10.2)
Recurrent site
0.933
Locoregional
16 (69.5)
10 (71.4)
6 (66.7)
Distance
5 (21.7)
3 (21.4)
2 (22.2)
Combined
2 (8.7)
1 (7.1)
1 (11.1)
Values are presented as number (%), median (IQR1-IQR3). FIGO: The International Federation of Gynecology and Obstetrics; OP: ovarian preservation; LVSI: lymph-vascular space invasion; LN: lymph node; DSI: deep stromal invasion; RT: radiotherapy; CCRT: concurrent chemoradiation; HRT: hormonal replacement therapy. a,bFIGO stage not having a superscript in common within clinicopathological characteristics differ significantly ( value < 0.05).
