Safety and Prognostic Impacts of Ovarian Preservation during Radical Hysterectomy for Early-Stage Adenocarcinoma and Adenosquamous Cervical Cancer
Table 2
Univariate analysis of 5-year recurrence-free survival and 5-year overall survival in patients aged <50 years.
Characteristic
5-year RFS (95% CI)
value
5-year OS (95% CI)
value
FIGO stage
0.01
0.043
IA2
100.0a
100.0a
93.1 (86.7-99.9)a
95.6 (89.7-100)a,b
85.7 (78.1-94.0)
97.3 (93.6-100)b
Histology
0.254
0.513
Adenocarcinoma
91.5 (86.7-96.5)
97.3 (94.4-100.0)
Adenosquamous
80.2 (64.4-100.0)
95.2 (86.6-100.0)
LVSI
0.042
0.016
No
90.9 (86.0-96.0)
96.7 (93.5-100.0)
Yes
82.2 (65.5-100.0)
100 (100-100.0)
Parametrial invasion
<0.001
<0.001
No
90.7 (85.9-95.7)
96.8 (93.8-100.0)
Yes
77.1 (53.5-100.0)
100 (100-100.0)
LN metastasis
<0.001
<0.001
No
92.3 (87.9-96.8)
97.8 (95.3-100.0)
Yes
38.1 (13.7-100.0)
80.0 (51.6-100.0)
Vaginal margin involvement
<0.001
0.213
No
90.3 (85.5-95.3)
97.0 (94.1-100.0)
Yes
75.0 (42.6-100.0)
100.0
DSI
0.004
0.003
No
91.8 (87.0-96.8)
96.3 (92.9-99.9)
Yes
81.8 (68.4-98.0)
100.0
Type of surgery
0.940
1
Open
89.9 (85.1-94.9)
97.0 (94.2-100.0)
Laparoscopic
100.0 (100-100.0)
100.0 (100.0-100.0)
Adjuvant treatment
<0.001
<0.001
No
92.3 (87.8-97.1)
97.5 (94.7-100.0)
Yes
75.2 (58.4-96.8)
94.4 (84.4-100.0)
Postoperative HRT
0.892
0.631
No
91.2 (85.7-96.9)
97.9 (95.1-100.0)
Yes
86.7 (73.7-100.0)
100 (100-100.0)
Missing
86.5 (73.4-100.0)
89.2 (76.0-100.0)
Year of treatment
0.778
0.503
1987-1999
88.0 (79.5-97.5)
95.8 (90.2-100.0)
2000-2017
91.2 (85.7-96.9)
97.7 (94.6-100.0)
Ovarian preservation
0.363
0.974
No
91.1 (84.4-98.3)
96.5 (91.8-100.0)
Yes
88.9 (82.2-96.1)
97.5 (94.2-100.0)
Values are presented as percentage (95% confidence interval). FIGO: The International Federation of Gynecology and Obstetrics; OP: ovarian preservation; LVSI: lymph-vascular space invasion; LN: lymph node; DSI: deep stromal invasion; HRT: hormonal replacement therapy. a,bFIGO stage not having a superscript in common within RFS and OS differ significantly ( value < 0.05).
