Screening of T Cell-Related Long Noncoding RNA-MicroRNA-mRNA Regulatory Networks in Non-Small-Cell Lung Cancer

Figure 1

(a) Volcano plot of DEGs in the Stromal score group, (b) Immune score, and (c) Venn plots of DEGs that are upregulated and (d) down regulated. (a) To screen the DEGs between the high score group vs. the low score group, the gene expression RNA-seq data (counts, FPKM) and clinical data (phenotype) of NSCLC-LUAD were downloaded from XENA. In total, 510 tumor samples were obtained. In the Stromal score group, 1,031 mRNAs (998 upregulated, 33 downregulated) and 200 lncRNAs (184 upregulated, 16 downregulated) were obtained. (b) A total of 940 mRNAs (886 upregulated, 54 downregulated) and 272 lncRNAs (250 upregulated, 22 downregulated) were obtained according to the Immune Score result. Blue dots represent downregulated genes. Red dots represent upregulated genes. Grey dots represent nondifferentially expressed genes. DEGs represent differentially expressed genes. (c, d) In order to further analyze the DEGs, the intersection of the two groups of DEGs was screened. A total of 885 upregulated RNAs (88 lncRNAs, 797 mRNAs) and 29 downregulated RNAs (8 lncRNAs, 21 mRNAs) were obtained. Purple represents the Immune score group of DEGs. Yellow represents the Stromal score group of DEGs. DEGs represent differentially expressed genes.

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