Screening of T Cell-Related Long Noncoding RNA-MicroRNA-mRNA Regulatory Networks in Non-Small-Cell Lung Cancer

Figure 6

The PPI network of (a) CD8(+) T cell-related DEGs and (b) memory-activated CD4(+) T cell-related DEGs. The interaction between gene coding proteins was predicted and analyzed using the STRING database. The PPI score was set at 0.4. After the PPI edges were obtained, Cytoscape software was used to construct a network for them, and survivor-related differential genes were identified from the network. The CytoNCA plug-in of the Cytoscape software was applied to analyze the topological properties (betweenness, closeness, and degree) of the network. Red nodes represent the upregulated mRNAs while blue nodes represent the downregulated mRNAs. The size of nodes represents the corresponding value. Larger nodes indicate a larger value. DEGs represent differentially expressed genes.

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