Review Article
Prognostic Value of Long Noncoding RNA SPRY4-IT1 on Survival Outcomes in Human Carcinomas: A Systematic Review and Meta-Analysis with TCGA Database
Table 1
Summary of the main characteristics of the studies enrolled in the meta-analysis.
| | First author | Year | Country | Sample size | SPRY4-IT1 expression | Tumor type | Sample type | Follow-up time (month) | Tumor stage | Cutoff value | Detection method | Metastasis | Survival analysis | Outcome | NOS | | High | Low |
| | Dong Cao | 2016 | China | 84 | 36 | 48 | CRC | Tissue | 36 | TNM I-IV | 2.87 | qRT-PCR | DM | M | OS | 7 | | Yang Cao | 2016 | China | 100 | 46 | 54 | Cervical cancer | Tissue | 60 | FIGO I-II | 2.76 | qRT-PCR | LNM | M | OS | 8 | | Wenlong Tan | 2017 | China | 106 | 58 | 48 | CRC | Tissue | N/A | TNM I-IV | Mean | qRT-PCR | DM/LNM | M | OS | 8 | | Min Xie | 2015 | China | 61 | 30 | 31 | Gastric cancer | Tissue | 36 | TNM I-IV | 0.535 | qRT-PCR | LNM | U | OS | 6 | | Guifang Yu | 2017 | China | 82 | 45 | 37 | HCC | Tissue | 60 | TNM I-IV | Median | qRT-PCR | N/A | U | OS | 8 | | Hongxia Li | 2017 | China | 124 | 62 | 62 | Ovarian cancer | Tissue | 60 | FIGO I-IV | Median | qRT-PCR | LNM | M | OS | 8 | | Teng Liu | 2016 | China | 70 | 32 | 38 | Melanoma | Blood | 60 | TNM I-IV | 2.64 | qRT-PCR | N/A | M | OS | 8 | | Wei Peng | 2015 | China | 175 | 98 | 77 | Gastric cancer | Tissue | 60 | TNM I-IV | 0.778 | qRT-PCR | DM | M | OS | 8 | | M Sun | 2014 | China | 121 | 60 | 61 | NSCLC | Tissue | 36 | TNM I-III | Median | qRT-PCR | LNM | M | OS | 9 | | Youqun Xiang | 2019 | China | 102 | 52 | 50 | Breast cancer | Tissue | N/A | TNM I-III | Mean | qRT-PCR | LNM | M | OS | 8 | | Hai-Wei Xie | 2014 | China | 92 | 46 | 46 | ESCC | Tissue | 60 | TNM I-IV | 4.52 | qRT-PCR | LNM | M | OS | 8 | | Hai-Min Zhang | 2014 | China | 98 | 52 | 46 | CCRCC | Tissue | 60 | TNM I-IV | 3.38 | qRT-PCR | DM/LNM | M | OS | 8 | | Xiao-Lei Zhao | 2015 | China | 68 | 38 | 30 | Bladder cancer | Tissue | 60 | TNM I-IV | 3.68 | qRT-PCR | LNM | M | OS | 7 | | Yi Xu | 2018 | China | 70 | 41 | 29 | CCA | Tissue | 60 | TNM I-IV | 2.65 | qRT-PCR | NA | M | OS | 7 | | Yue Yao | 2018 | China | 46 | 26 | 20 | PDAC | Tissue | 61 | TNM I-IV | 3.57 | qRT-PCR | NA | M | OS | 7 | | Y. Zhou | 2016 | China | 163 | 81 | 82 | Glioma | Tissue | N/A | TNM I-IV | Median | qRT-PCR | NA | M | OS | 7 | | Xia Zhang | 2017 | China | 88 | 44 | 44 | LUAD | Tissue | 60 | N/A | Median | qRT-PCR | NA | M | OS | 7 |
|
|
Abbreviations: CRC: colorectal cancer; HCC: hepatocellular carcinoma; NSCLC: non-small-cell lung cancer; ESCC: esophageal squamous cell carcinoma; CCRCC: clear cell renal cell carcinoma; CCA: cholangiocarcinoma; PDAC: pancreatic ductal adenocarcinoma; LUAD: lung adenocarcinoma; DM: distant metastasis; TNM: tumor node metastasis; FIGO: International Federation of Gynecology and Obstetrics; LNM: lymph node metastasis; N/A: not available; qRT-PCR: reverse transcription quantitative polymerase chain reaction; M: multivariate; U: univariate; NOS: Newcastle–Ottawa Scale; OS: overall survival.
|
