Prognostic Value of Long Noncoding RNA SPRY4-IT1 on Survival Outcomes in Human Carcinomas: A Systematic Review and Meta-Analysis with TCGA Database

Table 2

Stratified analyses of the pooled HRs of overall survival by sample size, tumor type, cutoff value, and follow-up time.

		Random-effects model		Fixed-effects model		Heterogeneity
Analysis	No. of studies	HR (95% CI)		HR (95% CI)
Subgroup 1:	8	1.896 (1.313~2.763)	<0.001	1.846 (1.501~2.272)	<0.001	66.90%	0.004
	9	2.046 (1.287~3.252)	0.002	1.863 (1.513~2.293)	<0.001	76.40%	<0.001
Subgroup 2: Digestive system	9	1.913 (1.381~2.650)	<0.001	1.869 (1.542~2.266)	<0.001	62.40%	0.006
Others	8	2.066 (1.196~3.567)	0.009	1.834 (1.462~2.302)	<0.001	79.20%	<0.001
Subgroup 3: Cutoff value: mean	5	2.543 (1.795~3.604)	<0.001	2.560 (1.884~3.477)	<0.001	19.50%	0.291
Cutoff value: median	7	1.491 (0.867~2.562)	0.149	1.479 (1.196~1.828)	<0.001	83.30%	<0.001
Cutoff value: 2^-ΔΔCt	5	2.194 (1.595~3.017)	<0.001	2.084 (1.589~2.734)	<0.001	15.30%	0.317
Subgroup 4: Follow-up	3	0.924 (0.288~2.966)	0.894	0.831 (0.567~1.217)	0.341	89.10%	<0.001
Follow-up	11	2.248 (1.789~2.826)	<0.001	2.108 (1.771~2.509)	<0.001	34.50%	0.122