Oltipraz Prevents High Glucose-Induced Oxidative Stress and Apoptosis in RSC96 Cells through the Nrf2/NQO1 Signalling Pathway

<div>JC-1 staining was used to detect cell apoptosis. (a) Fluorescence microscopy showed that the mitochondrial membrane potential of RSC96 cells was decreased (green fluorescence) in the high-glucose group compared with the control group. Oltipraz prevented mitochondrial damage as a result of treatment with high glucose. (b) Flow cytometry analysis showed that the red/green fluorescence ratio of cells in the high-glucose group was higher compared with the control group. Oltipraz treatment significantly increased the red/green fluorescence ratio compared with the high-glucose group. Scale bar, 50 <i>μ</i>m. 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BioMed Research International

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Figure 3

Figure 3: Oltipraz Prevents High Glucose-Induced Oxidative Stress and Apoptosis in RSC96 Cells through the Nrf2/NQO1 Signalling Pathway 