Significant Association of rs2147555 Genetic Polymorphism in the EDNRB Gene with Hirschsprung Disease in Southern Chinese Children

Table 2

Analysis of association of allelic frequencies of SNPs rs2147555 with HSCR.

	Cases/controls ()	Risk allele frequency in cases/controls			OR (95% CI)
SNP rs2147555
Total HSCR	1469/1473	0.107/0.085		0.018	1.291 (1.084-1.538)
S-HSCR	1034/1473	0.110/0.085	0.003	0.022	1.330 (1.100-1.608)
L-HSCR	295/1473	0.111/0.085	0.044	0.086	1.344 (1.007-1.794)	0.051
TCA	82/1473	0.091/0.085	0.781	0.917	1.081 (0.626-1.867)	0.778
TIA	3/1473	0.167/0.085	0.476	0.481	2.147 (0.250-18.45)	1

: unadjusted values; : adjusted values using logistic regression analysis by including the covariate of sex; : empirical values obtained by performing 100,000 Monte-Carlo simulations; OR: odds ratio; CI: confidence interval.