A Novel Three-miRNA Signature Identified Using Bioinformatics Predicts Survival in Esophageal Carcinoma

Table 3

Univariate and multivariate analysis in patients with esophageal cancer.

Variable	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Age at diagnosis
>60 vs. ≤60	0.931	0.576–1.506	0.771	0.933	0.567–1.534	0.783
Pathologic stage
III + IV vs. I + II	2.065	1.530–2.786	<0.001	1.995	1.299–3.064	0.002
T Stage
T3 + T4 vs. T1 + T2	1.474	1.055–2.060	0.023	1.144	0.813–1.611	0.440
Lymph node status
N1-2 vs. N0	1.395	1.120–1.738	0.003	1.048	0.805–1.365	0.726
Distant metastasis
M1 vs. M0	2.163	1.250–3.743	0.006	1.022	0.508–2.057	0.951
Three-miRNA signature
high-risk vs. low-risk	3.234	1.457–7.174	0.004	3.442	1.475–8.035	0.004

HR, hazard ratio; 95% CI, 95% confidence interval; vs., versus.