Curcumin Inhibits Proliferation and Epithelial-Mesenchymal Transition in Lens Epithelial Cells through Multiple Pathways

Figure 7

Curcumin suppressed TGF-β2-induced activation of the ERK1/2 and Akt pathway while the p38 pathway was not affected. (a) Expressions of p38, ERK1/2, Akt, and their phosphorylated forms in LECs treated with TGF-β2 (0, 10 ng/ml) and curcumin (0, 5, and 10 μM) for 48 h were detected by western blots. (b) Densitometric analyses of the protein expression levels of p38, p-p38, ERK1/2, p-ERK1/2, Akt, and p-Akt from the western blots are shown. GAPDH and tubulin were used as internal controls. ^# vs. the control, vs. treatment with TGF-β2 only.

(a)

(b)