Characterizations of Gene Alterations in Melanoma Patients from Chinese Population

Figure 1

Landscape of genetic alterations in melanomas in China. The patient information, clinical characterizations, and molecular subtypes are presented for patients (top). (In one case listed in BRAF subtype, primary melanoma has a BRAF V600E whereas no mutation of BRAF/RAS/NF1 was detected in the paired metastasis melanoma; one case listed in RAS subtype harbored co-mutation of KRAS G12R and BRAF L567V.) The total counts of germline mutation, the matrix of somatic mutation, and CNV gain are indicated (middle and bottom). Mutations in different types of melanoma specimens (primary or metastasis) are shown with different fillings. Frequencies (left) and numbers (right) of gene mutation in our cohort are listed.