Characterizations of Gene Alterations in Melanoma Patients from Chinese Population

Table 1

Clinical characterizations and gene alterations of the samples involved.

	No. of samples	CNV gains	Somatic mutations	No. of patients	Germline mutations
No. (percent)	39	32 (82.1%)	35 (89.7%)	27	27 (100%)
Total alterations		57	104		139
Age
<55	20	80	55	13	152
≥55	19	107	49	14	155
value		0.003	0.020		0.356
Gender
Male	22	89	44	16	184
Female	17	98	60	11	123
value		0.215	<0.001		0.677
Location
Acral skin	20	73	49	15	169
Cutaneous skin	18	106	52	11	127
value		0.004	0.482		0.610
TNM stage
II	6	35	25	5	55
III	19	73	39	13	151
IV	13	71	37	8	90
value		0.454	0.416		0.029
Lymph node metastasis
Positive	29	131	70	19	218
Negative	7	35	26	6	64
value		0.521	0.396		<0.001
Ulceration
Positive	19	99	60	13	151
Negative	17	67	36	12	131
value		0.315	0.656		0.051

These values were based on the comparison in the overall.