KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT

Figure 3

KIF3C modulates the expression of EMT and apoptosis-related proteins in vitro. (a) Overexpression of KIF3C increased N-cadherin, vimentin, snail, and slug expression to promote EMT in vitro, while KIF3C downregulation had the opposite effects. (b) Loss of KIF3C increased Bax levels and decreased Bcl-2 and cleaved caspase-3 expression, while overexpression of KIF3C had the opposite effects. (c, d) The same results were also found in U251 cells.

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