Identification of 5 Gene Signatures in Survival Prediction for Patients with Lung Squamous Cell Carcinoma Based on Integrated Multiomics Data Analysis

Table 4

Univariate and multivariate Cox regression analysis to identify prognostic clinical factors and clinical independence.

Variables	Univariate analysis			Multivariable analysis
	HR	95% CI of HR	value	HR	95% CI of HR	value
TCGA training datasets
5-gene risk score
Low-risk group	1 (reference)			1 (reference)
High-risk group	2.72	2.01-3.66	5.310-11	2.27	1.30601-3.936	0.004
Age	1.00	0.97-1.02	9.980-01	1.03	0.97001-1.093	0.33624
Gender female	1 (reference)			1 (reference)
Gender male	0.92	0.58-1.43	0.70	0.63	0.30321-1.301	0.21085
Smoke years	0.98	0.96-1.01	0.37	0.99	0.96278-1.015	0.40262
Pathologic T1	1 (reference)			1 (reference)
Pathologic T2	1.41	0.8314-2.381	0.20341	1.48	0.52948-4.114	0.45674
Pathologic T3	1.69	0.8693-3.283	0.122	1.74	0.2188-13.78	0.602
Pathologic T4	3.90	1.4234-10.69	0.008	13.87	0.25483-754.666	0.197
Pathologic N0	1 (reference)			1 (reference)
Pathologic N1	1.21	0.7879-1.857	0.384	0.54	0.10297-2.854	0.470
Pathologic N2/N3	0.77	0.3517-1.686	0.513	0.91	0.02173-37.89	0.959
Pathologic M0	1 (reference)			1 (reference)
Pathologic M1/MX	1.70	1.059-2.717	2.80E-02	3.65	1.58507-8.395	2.34-03
Tumor stage I	1 (reference)			1 (reference)
Tumor stage II	1.02	0.6474-1.615	0.924	1.46	0.32211-6.599	0.62452
Tumor stage III	1.27	0.7519-2.132	0.3749	0.89	0.0297-26.834	0.94791
Tumor stage IV	3.23	0.9983-10.429	0.050	1.31	0.08057-21.187	0.85
TCGA datasets, GSE42127
TCGA test datasets
5-gene risk score
Low-risk group	1 (reference)			1 (reference)
High-risk group	1.85	1.501-2.283	8.89-09	1.737	1.2456-2.423	1.14-03
Age	1.02	0.9995-1.033	0.058	1.029	0.9916-1.067	0.132
Gender female	1 (reference)			1 (reference)
Gender male	1.20	0.8669-1.646	0.277	1.240	0.7443-2.067	0.408
Smoke years	0.99	0.9739-1.007	0.26	0.99	0.973-1.01	0.349
Pathologic T1	1 (reference)			1 (reference)
Pathologic T2	1.25	0.8779-1.765	0.219	0.89	0.4878-1.629	0.708
Pathologic T3	1.82	1.1618-2.847	0.009	0.897	0.27-2.98	0.859
Pathologic T4	2.32	1.2481-4.327	0.008	1.014	0.2338-4.396	0.985
Pathologic N0	1 (reference)			1 (reference)
Pathologic N1	1.07	0.7824-1.466	0.669	0.687	0.2744-1.721	0.423
Pathologic N2	1.32	0.831-2.093	2.40-01	1.475	0.3304-6.588	0.611
Pathologic N3	2.51	0.6183-10.212	1.98-01	3.030	0.3645-25.18	0.305
Pathologic M0	1 (reference)			1 (reference)
Pathologic M1	3.18	1.3-7.778	1.13-02	1.472	0.1424-15.22	0.746
Pathologic MX	1.55	1.049-2.299	0.028	2.250	1.1797-4.293	0.014
Tumor stage	1 (reference)			1 (reference)
Tumor stage II	1.13	0.8234-1.559	4.43-01	1.011	0.4121-2.48	0.981
Tumor stage III	1.64	1.1622-2.311	4.84-03	1.351	0.2684-6.796	0.716
GSE42127
5-gene risk score
Low risk group	1 (reference)			1 (reference)
High risk group	2.07	1.133-3.778	0.018	2.33	1.1539-4.697	0.018
Age	1.03	0.9751-1.084	0.306	1.0127	0.9497-1.08	0.7002
Gender female	1 (reference)			1 (reference)
Gender male	1.196	0.4723-3.029	0.706	1.1037	0.4032-3.021	0.848
Tumor stage I	1 (reference)			1 (reference)
Tumor stage II	0.82	0.2549-2.643	0.741	1.00	0.2773-3.576	0.995
Tumor stage III	2.0311	0.7574-5.447	0.159	2.7395	0.9225-8.136	0.070