Effect of Carvacrol, TRP Channels Modulator, on Cardiac Electrical Activity

Figure 1

Representative traces of electrical activity registered on the Langendorff-perfused rabbit hearts. (a) Pseudo-ECGs under spontaneous rhythm in control conditions (black) and at 10, 30, 100, and 300 μM cumulatively increased concentrations of CAR (light green, green, dark green, and light blue, respectively) for 5 min under each condition, followed by 10 min perfusion without the drug (grey). (b) Superimposition of pseudo-ECG traces; same data as in (a). (c) Traces obtained from a unipolar electrogram of the LV under the same experimental conditions as in (a) but during epicardial stimulation. Note: marked slowing in conduction velocity (CV) and depression in T-wave amplitude at 300 μM CAR. Asterisk means electrogram traces presented in every 30 s (not after 5 min), when perfused with CAR at the 300 μM concentration (light blue, blue, dark blue, and navy, respectively).

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