Effect of Carvacrol, TRP Channels Modulator, on Cardiac Electrical Activity

Figure 2

CAR effects on the APs of the Langendorff-perfused rabbit hearts. (a) Representative traces of APs from microelectrodes obtained with atrial, endocardial, and epicardial pacing under control conditions (i.e., Tyrode solution; black) and at 10, 30, 100, and 300 μM cumulatively increased concentrations of CAR (light green, green, dark green and light blue, respectively). Insert: CAR concentrations as indicated in μM. The broken black arrow indicates the start of the stimulus. Solid arrows denote the rightward shift in the AP activation time. (b) Superimposition of AP upstrokes from the same data as in (a). Note change in AP activation times vs. CAR concentrations as indicated. (c) Traces of (in V/s) obtained at increased concentrations of CAR. AP upstroke velocity values were obtained from the same AP data as in (a). Note the marked decrease in conduction at 300 μM CAR (light blue).