Effect of Carvacrol, TRP Channels Modulator, on Cardiac Electrical Activity

Figure 5

CAR effects on cardiac electrical activity in a human LV preparation obtained using the fluorescent dye di-4-ANBDQBS. (a) (left to right) schematic view of experimental setup, LV wedge preparation cannulated via left anterior descending coronary artery (LAD), ECG, superimposed OAPs (upper), and their upstrokes (lower); control (black) and 100 μM CAR (green) treatments. Endocardial pacing was set at a 2000 ms period. Representative optical maps obtained during control (b) and 100 μM CAR treatments (c): (left to right) activation time (AT), conduction velocity (CV), conduction vector (C-vector), and OAPD maps (OAPD20, OAPD50, and OAPD90). The corresponding scale bars are given at the bottom. Other notations are the same as in Figure 4.