Effect of Carvacrol, TRP Channels Modulator, on Cardiac Electrical Activity

Table 1

The mean data of standard AP parameters in a Langendorff-perfused rabbit heart.

Pacing	AT		APA	APD20	APD50	APD90	RP
	(ms)	(V/s)	(mV)	(ms)	(ms)	(ms)	(mV)
Atrial
Control
CAR10
CAR30
CAR100
CAR300	~226.9	~109.5	~97.9	~46.9	~77.7	~122	-78.4
Endo-
Control
CAR10
CAR30
CAR100
CAR300
Epi-
Control
CAR10
CAR30
CAR100
CAR300

Control: Tyrode solution containing blebbistatin (10 μM); CAR10-300: carvacrol effects with the maximal changes in APD at 10 μM, 30 μM, 100 μM, and 300 μM CAR concentrations, respectively; RP: resting membrane potential; APA: action potential (AP) amplitude; APD20, APD50, and APD90: AP duration at 20%, 50%, and 90% levels of repolarization, respectively; : the maximal value of the first time derivative of the AP upstroke; AT: activation time. Statistical analysis was performed using ANOVA, for CAR vs. control, for each during atrial and epicardial pacing, and for each during endocardial pacing. Note that the data presented at 300 μM CAR under atrial pacing are from one successful measurement. The of the mean was not determined because of the appearance of atrioventricular blocks. The average depth of microelectrode insertion was from the epicardium.