H-Type Hypertension Is a Risk Factor for Cerebral Small-Vessel Disease

Table 4

The association of risk factors with CSVD total burden.

Risk factors	Single factor analysis		Multiple analysis
	OR (95%CI)		OR (95%CI)
Age	1.048 (1.029–1.067)	0.000	1.059 (1.037–1.082)	0.000
Gender	0.913 (0.577–1.446)	0.073	0.632 (0.373–1.071)	0.088
Diabetes mellitus	1.413 (0.800–2.497)	0.234	1.387 (0.694–2.770)	0.588
Cardiac diseases	1.456 (0.819–2.594)	0.203	1.068 (0.544–2.096)	0.345
Systolic pressure	1.026 (1.013–1.040)	0.000	1.122 (1.007–1.136)	0.006
Diastolic pressure	1.020 (1.001–1.039)	0.037	1.014 (0.989–1.041)	0.276
Total cholesterol	1.018 (0.819–1.266)	0.871	0.823 (0.631–1.073)	0.062
Triglycerides	1.200 (0.948–1.518)	0.129	1.386 (1.037–1.854)	0.015
LDL	1.046 (0.800–1.368)	0.742	1.123 (0.549–2.296)	0.549
HDL	0.798 (0.394–1.617)	0.531	0.657 (0.251–1.720)	0.854
Glucose	1.040 (0.944–1.145)	0.430	0.957 (0.854–1.07)	0.456
Uric acid	1.001 (0.999–1.004)	0.225	1.001 (0.998–1.004)	0.521
Hs-CRP	1.020 (0.982–1.061)	0.305	1.010 (0.964–1.059)	0.980
Control	1.000		1.000
Isolated hypertension	3.339 (1.751–6.369)	0.000	1.611 (0.779–3.333)	0.198
Isolated HHcy	5.317 (2.469–11.447)	0.011	4.154 (1.836–9.401)	0.001
H-type hypertension	9.667 (4.725–19.778)	0.022	5.028 (2.323–10.883)	0.007
HBP by Hcy	3.694 (2.142–6.373)	0.009	2.776 (1.564–4.927)	0.002