Irisin Pretreatment Protects Kidneys against Acute Kidney Injury Induced by Ischemia/Reperfusion via Upregulating the Expression of Uncoupling Protein 2

Figure 7

Proposed potential working model of irisin modulation of UCP2 in renal proximal tubular epithelial cells. Irisin activated the AMPK signaling pathway and upregulated the expression of UCP2, which ameliorated I/R-induced renal injury.