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No. | Gene symbol | Full name | Function |
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1 | MALAT1 | Metastasis-associated lung adenocarcinoma transcript 1 | Form molecular scaffolds for ribonucleoprotein complexes, acting as a transcriptional regulator for numerous genes, and involved in cell cycle regulation |
2 | RNU1-1 | RNA, U1 small nuclear 1 | Its related pathways are spliceosomal splicing cycle |
3 | FENDRR | FOXF1 adjacent noncoding developmental regulatory RNA | Bind to polycomb repressive complex 2 and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes |
4 | TUG1 | Taurine upregulated 1 | Interacts with the polycomb repressor complex and functions in the epigenetic regulation of transcription, acting as a sponge for microRNAs |
5 | E2F1 | E2F transcription factor 1 | Bind preferentially to retinoblastoma protein pRB in a cell cycle-dependent manner and mediate both cell proliferation and p53-dependent/independent apoptosis |
6 | TP53 | Tumor protein P53 | Regulate expression of target genes, inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism |
7 | SP1 | Sp1 transcription factor | Be involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling |
8 | YBX1 | Y-box binding protein 1 | Be implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation, and mRNA packaging |
9 | BRCA1 | Breast cancer type 1 susceptibility protein | Play a role in transcription, DNA repair of double-stranded breaks, and recombination which forms a large multisubunit protein complex known as the BRCA1-associated genome surveillance complex and interacts with histone deacetylase complexes |
10 | E2F4 | E2F transcription factor 4 | Act as proliferation-associated suppression genes and bind to all three of the tumor suppressor proteins pRB, p107, and p130 |
11 | CREB1 | CAMP responsive element binding protein 1 | Its related pathways are development of HGF signaling pathway and circadian entrainment |
12 | CIITA | Class II major histocompatibility complex transactivator | Once it does not bind DNA but rather uses an intrinsic acetyltransferase activity to act in a coactivator-like fashion |
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