Catalpol Attenuates Hepatic Steatosis by Regulating Lipid Metabolism via AMP-Activated Protein Kinase Activation

<div>Catalpol inhibits palmitate- (PA-) induced triglyceride (TG) accumulation in HepG2 cells. HepG2 cells were treated with PA (300 <i>μ</i>M) and/or catalpol (100, 200, or 400 <i>μ</i>M) for 24 h. (a) Lipid accumulation was determined via Oil Red O staining. Images of cells were photographed at 200x magnification: (i) control, (ii) PA (300 <i>μ</i>M), (iii) PA (300 <i>μ</i>M)+catalpol (100 <i>μ</i>M), (iv) PA (300 <i>μ</i>M)+catalpol (200 <i>μ</i>M), and (v) PA (300 <i>μ</i>M)+catalpol (400 <i>μ</i>M). (b) A larger red area consisting of lipid droplets in HepG2 cells. (c) Measurement of intracellular TG content. 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BioMed Research International

fig1

Figure 1

Figure 1: Catalpol Attenuates Hepatic Steatosis by Regulating Lipid Metabolism via AMP-Activated Protein Kinase Activation 