Research Article
AKNA Is a Potential Prognostic Biomarker in Gastric Cancer and Function as a Tumor Suppressor by Modulating EMT-Related Pathways
Table 2
The relationship between AKNA expression level and clinicopathological factors in 32 GC cases.
| Characteristics | | Expression of AKNA | | | Low () | High () |
| Gender | | | | | 0.685 | Male | 24 | 13 (54.2%) | 11 | | | Female | 8 | 3 (37.5%) | 5 | | | Age(years) | | | | 4.800 | 0.028 | ≤60 | 12 | 9 (75.0%) | 3 | | | >60 | 20 | 7 (35.0%) | 13 | | | Borrmann’s types | | | | | 0.433 | I+II | 9 | 6 (66.7%) | 3 | | | III | 23 | 10 (43.5%) | 13 | | | Lauren’s types | | | | 0.533 | 0.465 | Intestinal type | 12 | 7 (58.3%) | 5 | | | Diffuse type | 20 | 9 (45.0%) | 11 | | | Depth of invasion | | | | 3.463 | 0.063 | T1~T3 | 11 | 3 (27.3%) | 8 | | | T4 | 21 | 13 (61.9%) | 8 | | | Ln metastasis | | | | 8.533 | 0.003 | N0 | 12 | 2 (16.7%) | 10 | | | N1~N3 | 20 | 14 (70.0%) | 6 | | | Distant metastasis | | | | | 1.000 | M0 | 31 | 15 (48.4%) | 16 | | | M1 | 1 | 1 (100%) | 0 | | | TNM staging | | | | 1.166 | 0.280 | I+II | 13 | 5 (38.5%) | 8 | | | III+IV | 19 | 11 (57.9%) | 8 | | |
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Fisher’s exact test. Ln.: lymph node. |