Research Article
Hyperhomocysteinemia Associated with Multiple Organ Failure in Acute Pancreatitis Patients
Table 1
Comparison of clinical characteristics and outcomes between the hyperhomocysteinemia group and the control group.
| | Variable | Control group
Homocysteine level <15 µmol/L
N = 1371 | Study group
Homocysteine level ≥15 µmol
N = 509 | value |
| | Demographics and comorbidities | | Median age, years, mean (SD) | 49.15 (13.51) | 50.93 (15.58) | 0.015 | | Male sex, N (%) | 751 (54.77) | 372 (73.08) | <0.001 | | Hypertension, N (%) | 244 (17.79) | 111 (21.81) | 0.039 | | Diabetes mellitus, N (%) | 137 (9.99) | 81 (15.91) | 0.002 | | Apoplexy, N (%) | 32 (2.33) | 70 (13.75) | <0.001 | | Hyperlipidemia, N (%) | 190 (13.86) | 77 (15.13) | 0.489 |
| | Etiology | | | <0.001 | | Biliary, N (%) | 576 (42.01) | 238 (46.76) | | | Hypertriglyceridemia, N (%) | 622 (45.37) | 197 (38.70) | | | Alcohol, N (%) | 76 (5.54) | 41 (8.06) | | | Others, N (%) | 97 (7.08) | 33 (6.48) | |
| | Outcomes | | Surgery accepted, N (%) | 143 (10.43) | 68 (13.36) | 0.070 | | Pancreatic necrosis, N (%) | 257 (18.7) | 145 (28.5) | <0.001 | | ICU admission, N (%) | 157 (11.45) | 105 (20.63) | <0.001 | | Median hospital days (IQR) | 10.00 (7.00–15.00) | 10.00 (6.00–16.00) | 0.576 | | APACHE II score, mean (SD) | 5.13 (3.34) | 8.46 (6.00) | <0.001 | | CCI, mean (SD) | 1.45 (0.98) | 1.69 (1.24) | 0.023 | | Infection, N (%) | 72 (5.25) | 36 (7.07) | 0.132 | | Renal failure and CRRT, N (%) | 15 (1.10) | 44 (8.64) | <0.001 | | Multiple organ failure, N (%) | 285 (20.77) | 162 (31.83) | <0.001 | | Mortality | 28 (2.0%) | 33 (6.5%) | <0.001 |
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ICU: intensive care unit; APACHE II: acute physiology and chronic health evaluation scoring system II; SD: standard deviation; IQR: interquartile range; CRRT: continuous renal replacement therapy; CCI: Charlson Comorbidity Index.
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