Hyperhomocysteinemia Associated with Multiple Organ Failure in Acute Pancreatitis Patients

Table 2

Comparison of variables between the MOF group and the non-MOF group.

Variable	Non-MOF group; N = 1433	MOF group; N = 447	value
Demographics and comorbidities
Median ages, years, mean (SD)	51.14 (14.24)	49.16 (14.05)	0.826
Male sex, N (%)	869 (60.64)	254 (56.82)	0.151
Hypertension, N (%)	253 (17.66)	102 (22.82)	0.030
Diabetes mellitus, N (%)	203 (14.17)	66 (14.77)	0.916
Apoplexy, N (%)	81 (5.65)	21 (4.70)	0.109
Hyperlipidemia, N (%)	200 (13.96)	67 (14.98)	0.800
Etiology			0.002
Biliary, N (%)	595 (41.52)	219 (49.00)
Hypertriglyceridemia, N (%)	633 (44.17)	186 (41.61)
Alcohol, N (%)	91 (63.50)	26 (5.82)
Others, N (%)	114 (7.96)	16 (3.58)
Outcomes
Surgery accepted, N (%)	112 (7.82)	99 (22.15)	<0.001
Pancreatic necrosis, N (%)	23 (1.61)	379 (84.79)	<0.001
ICU admission, N (%)	8 (0.56)	254 (56.82)	<0.001
Median hospital days (IQR)	9.00 (6.00–13.00)	16.00 (10.00–27.00)	<0.001
APACHE II score, mean (SD)	4.22 (2.47)	9.81 (5.36)	<0.001
CCI, mean (SD)	1.37 (0.88)	2.30 (1.67)	<0.001
Infection, N (%)	2 (0.14)	106 (23.71)	<0.001
Mortality, N (%)	0 (0)	61 (13.65)	<0.001
CRP, mg/L (IQR)	0 (0.00–14.00)	136 (0.00–219.00)	<0.001
WBC, ×10^3/µL, mean (SD)	14.78 ± 6.53	11.76 ± 5.65	<0.001
PCT, (IQR)	0.00 (0.00–0.16)	0.00 (0.00–0.55)	0.287
HCY, µmol/L (SD)	12.78 (9.53)	14.69 (10.59)	<0.001
HCT, %, mean (SD)	38.77 (9.32)	39.60 (6.21)	<0.001
BUN, mmol/L, mean (SD)	5.09 (3.86)	8.17 (7.02)	<0.001
Creatinine, µmol/L, mean (SD)	69.19 (58.69)	107.59 (106.06)	<0.001
TG, mmol/L, mean (SD)	4.61 (7.82)	4.59 (5.61)	0.789
HDL-C, mmol/L, mean (SD)	0.96 (0.54)	0.78 (0.55)	0.254
LDL-C, mmol/L, mean (SD)	2.41 (1.71)	2.44 (1.29)	0.716
LDH, U/L (IQR)	226.60 (169.80–316.33)	462.82 (285.90–743.05)	<0.001
Glucose, mmol/L, mean (SD)	7.90 (5.74)	9.87 (4.69)	0.014
TC, mmol/L, mean (SD)	5.53 (4.53)	5.04 (4.47)	0.086
TBA, µmol/L (IQR)	2.10 (0.80–5.30)	2.80 (1.20–7.40)	0.273
Myoglobin, µg/L (IQR)	44.30 (31.30–65.60)	85.90 (48.60–225.05)	<0.001
Creatine kinase, U/L (IQR)	64.80 (41.40–108.10)	123.05 (50.33–369.40)	<0.001

WBC: white blood cell; HCT: hematocrit; PCT: procalcitonin; CRP: C-reactive protein; BUN: blood urea nitrogen; TC: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; LDH: lactic dehydrogenase; TBA: total bile acids.