Synergistic Utilization of Necrostatin-1 and Z-VAD-FMK Efficiently Promotes the Survival of Compression-Induced Nucleus Pulposus Cells via Alleviating Mitochondrial Dysfunction

<div>Nec-1+Z-VAD efficiently rescued 24 and 36 h compression-mediated MMP loss and MPTP opening in NP cells. (a) Representative dot plot images after JC-1 staining by flow cytometry in NP cells. (b) The quantitative analysis of JC-1 fluorescence intensity was expressed as the red/green ratio in NP cells. (c) The quantitative analysis of RFI of MPTP in NP cells by flow cytometry. 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BioMed Research International

fig6

Figure 6

Figure 6: Synergistic Utilization of Necrostatin-1 and Z-VAD-FMK Efficiently Promotes the Survival of Compression-Induced Nucleus Pulposus Cells via Alleviating Mitochondrial Dysfunction 

Figure 6 | Synergistic Utilization of Necrostatin-1 and Z-VAD-FMK Efficiently Promotes the Survival of Compression-Induced Nucleus Pulposus Cells via Alleviating Mitochondrial Dysfunction 