Phospholipase D1 Ameliorates Apoptosis in Chronic Renal Toxicity Caused by Low-Dose Cadmium Exposure

<div>Measurements of kidney impairment in rats exposed to chronic Cd for 12 weeks. (a) The concentration of Cd in kidney tissue and rat urine detected by using ICP-MS. (b) Pathohistological changes in kidney tissue produced by Cd exposure (Periodic Acid-Schiff stain, HE ×400). (c) Cleaved Caspase-3 was increased after Cd exposure. (d) Early biomarkers of kidney injury in urine detected with ELISA. Rats exposed to CdCl<sub>2</sub> at 0.6 mg/kg/d for 5 days per week for 12 weeks. 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BioMed Research International

fig1

Figure 1

Figure 1: Phospholipase D1 Ameliorates Apoptosis in Chronic Renal Toxicity Caused by Low-Dose Cadmium Exposure 