| | Pathway enrichment analysis | Genes |
| | R-HSA-913531: interferon signaling | HSPB1, RSAD2, OAS2, OASL, IFIT1, HERC5, OAS3, IFIT3, ISG15, IFI27, IFI44L, IFITM1, MX2, USP18, IFI44, CUL1, RTP4, IFI6, IFI35, MX1, EIF2AK2, IFIH1, LTF, XAF1, IFITM2, DDX60, IFIT5, IFIT2, TRIM22, CHMP5, PLSCR1, IFITM3, PSMB9, LHFPL2, UBE2L6, TRIM34, IRF7, ZBP1, BST2, IL1RN, RNASE2, STAT1, FCGR1B, IFI16, DEFA1, TRIM21, DDX58, CCL2, CCR5, STAP1, OPTN, CXCL10, ADAR, PLAC8, FOXO1, LGALS9, FCGR1A, CIITA, GBP1 | | GO:0034341: response to interferon-gamma | RSAD2, OAS2, OASL, IFIT1, OAS3, IFITM1, CUL1, MX1, EIF2AK2, IFIH1, TAP1, IFITM2, TRIM22, IFITM3, TRIM34, IRF7, BST2, STAT1, FCGR1B, TNFSF10, IFI16, TRIM21, DDX58, CCL2, GCH1, CXCL10, ADAR, LGALS9, FCGR1A, CIITA, GBP1 | | R-HSA-1169410: Antiviral mechanism by IFN-stimulated genes | RSAD2, OAS2, OASL, IFIT1, HERC5, AS3, ISG15, MX2, USP18, MX1, EIF2AK2, IFIH1, LTF, DDX60, GPR18, UBE2L6, IRF7, BST2, STAT1, DDX58, ANXA4, OPTN, LGALS9, GBP1 | | GO:0035455: response to interferon-alpha | IFIT1, IFIT3, IFITM1, MX2, EIF2, AK2, XAF1, IFITM2, IFIT2, PLSCR1, IFITM3, BST2, STAT1, IFI16, DEFA1, TRIM21, CCR5, ADAR, LGALS9 | | GO:0001817: regulation of cytokine product | HSPB1, RSAD2, HERC5, ISG15, EIF2AK2, IFIH1, LTF, DDX60, SORL1, GPR18, UBE2L6, IRF7, ZBP1, BST2, STAT1, IFI16, TRIM21, DDX58, IGF2BP3, ANXA4, LGALS9, GBP1 | | GO:0045088: regulation of innate immune response | RSAD2, USP18, CUL1, IFIH1, LTF, DDX60, LSCR1, PSMB9, IRF7, ZBP1, STAT1, FCGR1B, IFI16, DDX58, CTSL, STAP1, OPTN, ADAR, LGALS9, FCGR1A, GBP1, CD38 | | GO:0098586: cellular response to virus | HSPB1, RSAD2, NR2F6, IFIT1, ISG15, IFI27, IFI6, IFIH1, LTF, DDX60, SORL1, GPR18, IPO5, IRF7, ZBP1, IL1RN, STAT1, DEFA1, DDX58, CCL2, CCR5, ANXA4, CXCL10, ADAR, FOXO1, LGALS9, NR1D2, GBP1, CD38 | | GO:0060759: regulation of response to cytokine stimulus | SP18, IFIH1, IRF7, ZBP1, IL1RN, STAT1, DDX58, STAP1, CXCL10, ADAR | | GO:0009617: response to bacterium | HSPB1, NR2F6, OAS2, ISG15, IFITM1, IFI44, LTF, DDX60, CHMP5, HERC6, GPR18, RHOB, BST2, IL1RN, RNASE2, IFI16, PID1, DEFA1, TRIM21, CCL2, CCR5, STAP1, GCH1, OPTN, CXCL10, ADAR, PLAC8, FOXO1, LGALS9, NR1D2 | | GO:0043122: regulation of I-kappaB kinase/NF-kappaB signaling | HSPB1, EIF2AK2, LTF, ARID5B, IFIT5, TRIM22, GPR18, TRIM34, BST2, STAT1, TNFSF10, RIM21, DDX58, ANXA4, OPTN, LGALS9 | | R-HSA-983169: class I MHC-mediated antigen processing and presentation | HERC5, IFI27, SIGLEC1, IFITM1, CUL1, RASGRP3, TAP1, PLSCR1, PSMB9, HERC6, UBE2L6, FCGR1B, TRIM21, CTSL, STAP1, ATP6V0C, FCGR1A, GBP1, CD38 | | GO:0071888: macrophage apoptotic process | IRF7, CTSL, CCR5, LGALS9 | | GO:0043902: positive regulation of multiorganism process | IFIT1, DDX60, LHFPL2, TRIM21, OPTN, ADAR, LGALS9 | | GO:0070555: response to interleukin-1 | UL1, RASGRP3, PSMB9, IL1RN, STAT1, PID1, CCL2, CCR5, GCH1, CXCL10, FOXO1, H2AC18, H2AC19, LGALS9, GBP1, CD38 | | GO:0031400: negative regulation of protein modification process | HSPB1, IFIT1, ISG15, IFIH1, SORL1, CHMP5, IPO5, SKI, PRR7, STAT1, TNFSF10, PID1, TRIM21, DDX58, STAP1, ATP6V0C, ADAR, FOXO1, CRTAP, GBP1 | | GO:0061025: membrane fusion | MX2, MX1, TAP1, SAMD9, CCR5, OTOF | | R-HSA-977225: amyloid fiber formation | USP18, IFIH1, LTF, SORL1, PSMB9, UBE2L6, TRIM21, DDX58, UNG, H2AC18, H2AC19, FCGR1A | | GO:2000116: regulation of cysteine-type endopeptidase activity | HSPB1, ISG15, IFI27, CUL1, IFI6, LTF, SORL1, PSMB9, IRF7, PRR7, BST2, STAT1, TNFSF10, IFI16, ADAR, PABPC4, LGALS9, CD38 | | GO:0045055: regulated exocytosis | LGALS3BP, IFI27, EIF2AK2, ADGRE3, LTF, PLSCR1, LHFPL2, BST2, RNASE2, DEFA1, DDX58, ENPP4, OTOF, STAP1, UNG, ATP6V0C, OPTN, CXCL10, PLAC8, LGALS9, SCCPDH | | GO:0001881: receptor recycling | MX2, MX1, SORL1, CHMP5, OPTN |
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