Promotion of Bone Formation by Red Yeast Rice in Experimental Animals: A Systematic Review and Meta-Analysis

Table 1

Basic information of the articles.

Included studies	Group size		Intervention measures		Intervention time	Outcome indicators
	RYR	Control	RYR	Control
Wang et al. 2015 [11]	10	10	6.24 g/kg RYR extract	10 mL/kg saline	20 w	(1)
Wong and Rabie 2008 [12]	8	8	RYR medium	Blank control medium	48 h	(2)(3)
Cho et al. 2010 [13]	6	6	RYR medium	Blank control medium	5 d	(2)(3)
Lu et al. 2006 [14]	8	8	10 mL/kg RYR extract	10 mL/kg saline	10 d	(2)(3)
Lu et al. 2017 [15]	10	10	10 mL/kg RYR extract	10 mL/kg distilled water	12 w	(1)(3)
Lu et al. 2004 [16]	10	10	10 mL/kg RYR extract	10 mL/kg saline	12 w	(1)
Lu et al. 2005 [17]	10	10	10 mL/kg RYR extract	10 mL/kg saline	12 w	(2)
Shen et al. 2018 [18]	10	10	10 mL/kg RYR extract	10 mL/kg 0.9% sodium chloride solution	12 w	(1)
Lv et al. 2016 [19]	9	9	0.5 RYR capsule/kg	5 mL/kg distilled water	60 d	(1)
Yang and Zhang 2012 [20]	8	8	RYR extract	Saline	12 w	(1)(3)
Ye and Yang 2007 [21]	6	6	RYR medium	Blank control medium	72 h	(2)(3)

(1): bone mineral density (BMD); (2): osteoblast proliferation; (3): alkaline phosphatase (ALP) expression.