Inhibition of Distinct Proline- or N-Acetylglucosamine-Induced Hyphal Formation Pathways by Proline Analogs in Candida albicans

Table 1

Hyphal formation ability with amino acid in C. albicans.

Amino acid	Concentration (mg/mL)	Hyphal formation
L-alanine	4.0	+
L-cysteine	0.4	-
L-aspartic acid	4.0	-
L-glutamic acid	4.0	+
L-phenylalanine	2.0	+
Glycine	4.0	-
L-histidine	0.4	-
L-methionine	0.4	-
L-asparagine	1.4	-
L-glutamine	2.0	-
L-arginine	4.0	+
L-serine	2.0	-
L-isoleucine	0.2	-
L-threonine	0.2	-
L-hydroxyproline	2.0	-
L-proline	1.0	+++
Water control		-

-: <5% hyphal formation; +: >5% to <25% hyphal formation;++: >25% to <50% hyphal formation; +++: >50% hyphal formation.