Treatment with Minocycline Suppresses Microglia Activation and Reverses Neural Stem Cells Loss after Simulated Microgravity

Figure 6

Microgravity changed the concentration of some inflammatory cytokines in rat hippocampus. The levels of INF-γ (a), TNF-α (b), IL-1α (c), IL-1β (d), IL-6 (e), and IL-10 (f) in supernatants of hippocampal tissue collected after 7-, 14-, or 28-day tail suspension were observed separately. Compared with control groups, the concentrations of INF-γ and TNF-α were much higher in TS groups at different time points. However, the concentration of other factors, such as IL-1α, IL-1β, IL-6, and IL-10, did not change much between the control and TS groups. versus control (Bonferroni post hoc test after one-way ANOVA).

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