Research Article

The Survival Advantage of Females at Premenopausal Age Is Race Dependent in Colorectal Cancer

Table 2

Sex differences in clinicopathologic characteristics in colorectal cancer stratified by age.

CharacteristicPremenopausal age (≤45 yrs)Menopausal age (46–54 yrs)Postmenopausal age (≥55 yrs)
Male (%)Female (%) valueMale (%)Female (%) valueMale (%)Female (%) value

Tumour location<0.001<0.001<0.001
 Colon19,00 (70.4)1,861 (75.5)4,446 (71.4)3,802 (76.5)22,361 (78.4)22,870 (84.9)
 Rectum799 (29.6)604 (24.5)1,783 (28.6)1,171 (23.5)6,159 (21.6)4,056 (15.1)
Grade0.010.6<0.001
 Well differentiated180 (7.3)155 (6.8)549 (9.9)475 (10.5)2,518 (9.7)2,269 (9.1)
 Moderately differentiated1,668 (68.1)1,664 (72.9)4,113 (74.1)3,338 (73.5)19,111 (73.6)17,393 (69.8)
 Poorly differentiated or undifferentiated602 (24.6)463 (20.3)892 (16.1)729 (16.1)4,320 (16.6)5,271 (21.1)
TNM stage0.180.450.54
 077 (2.9)68 (2.8)274 (4.4)209 (4.2)1,018 (3.6)829 (3.1)
 I400 (14.8)441 (17.9)1,513 (24.3)1,189 (23.9)7,373 (25.9)6.748 (25.1)
 II606 (22.5)523 (21.2)1,356 (21.8)1,064 (21.4)8,015 (28.1)7.982 (29.6)
 III1,009 (37.4)876 (35.5)1,920 (30.8)1,581 (31.8)7,773 (27.3)7,521 (27.9)
 IV607 (22.5)557 (22.6)1,166 (18.7)930 (18.7)4,341 (15.2)3,846 (14.3)
Marital status0.001<0.001<0.001
 Married1,453 (56.4)1,398 (59.8)3,680 (63.3)2,786 (60.0)17,792 (66.4)10,739 (42.6)
 Widowed7 (0.3)19 (0.8)50 (0.9)126 (2.7)2,341 (8.7)8,320 (33.0)
 Others1,115 (43.3)919 (39.3)2,079 (35.8)1,730 (37.3)6,657 (24.8)6,155 (24.4)

Significant value. Abbreviation: TNM: tumour-node-metastasis.