The Survival Advantage of Females at Premenopausal Age Is Race Dependent in Colorectal Cancer

Table 3

Univariate and multivariate analyses for the prognostic value of sex stratified by age.

Age group	Univariate		Multivariate^§
	value	HR (95% CI)	value	HR (95% CI)
Premenopausal age (≤45 yrs)	<0.001	0.70 (0.59–0.84)	0.002	0.73 (0.60–0.89)
Menopausal age (46–54 yrs)	0.09	0.89 (0.79–1.02)	0.09	0.88 (0.77–1.02)
Postmenopausal age (≥55 yrs)	<0.001	1.12 (1.07–1.17)	0.13	0.96 (0.91–1.01)

Significant value. Abbreviation: TNM: tumour-node-metastasis. ^§Sex differences of prognosis were adjusted by tumour location (colon/rectum), grade (well differentiated/moderately differentiated/poorly differentiated or undifferentiated), TNM stage (0/I/II/III/IV), race (American Indian/Alaska Native/Asian or Pacific Islander/Black/White), insurance status (insured/others), marital status (married/widowed/others), and surgery for primary tumours (no/yes) in multivariate analysis.