The Neutrophil Percentage-to-Albumin Ratio as a New Predictor of All-Cause Mortality in Patients with Cardiogenic Shock

Table 4

The association between three NPAR groups and all-cause in-hospital mortality in subgroup analysis.

		Group I	Group II		Group III
Characteristics	No. of patients	Ref	HR (95% CI)	value	HR (95% CI)	value	value for interaction
Age, years							0.104
≤72	450	1	2.26 (1.39, 3.70)	0.001	3.98 (2.38, 6.64)	<0.001
>72	441	1	2.55 (1.71, 3.78)	<0.001	3.15 (2.05, 4.82)	<0.001
Sex							0.673
Male	532	1	2.11 (1.42, 3.13)	<0.001	2.57 (1.66, 3.98)	<0.001
Female	359	1	2.98 (1.81, 4.91)	<0.001	5.59 (3.34, 9.36)	<0.001
Smoking							0.412
No	428	1	2.91 (1.92, 4.40)	<0.001	3.01 (1.93, 4.70)	<0.001
Yes	463	1	2.33 (1.47, 3.69)	<0.001	5.01 (3.07, 8.17)	<0.001
Etiology							0.263
AMI	671	1	3.62 (1.31, 10.01)	0.013	9.10 (3.37, 24.59)	<0.001
AHF	179	1	2.67 (1.30, 5.48)	0.008	2.81 (1.72, 5.86)	0.004
CHF							0.188
No	701	1	2.51 (1.75, 3.61)	<0.001	4.67 (3.16, 6.89)	<0.001
Yes	190	1	2.64 (1.48, 4.73)	0.001	2.80 (1.53, 5.13)	0.001
AF							0.215
No	460	1	2.09 (1.36, 3.22)	0.001	3.49 (2.20, 5.56)	<0.001
Yes	431	1	3.16 (2.03, 4.93)	<0.001	4.03 (2.52, 6.45)	<0.001
CAD							0.305
No	419	1	3.05 (1.94, 4.80)	<0.001	4.52 (2.82, 7.26)	<0.001
Yes	472	1	2.13 (1.40, 3.24)	<0.001	3.11 (1.96, 4.95)	<0.001
Hypertension							0.502
No	714	1	2.96 (2.06, 4.25)	<0.001	4.30 (2.95, 6.27)	<0.001
Yes	177	1	1.57 (0.87, 2.82)	0.131	2.38 (1.17, 4.85)	0.017
DM							0.890
No	559	1	2.59 (1.77, 3.79)	<0.001	3.22 (2.15, 4.82)	<0.001
Yes	332	1	2.70 (1.59, 4.59)	<0.001	5.27 (2.98, 9.33)	<0.001
CKD							0.807
No	651	1	2.95 (2.01, 4.34)	<0.001	4.44 (2.98, 6.63)	<0.001
Yes	240	1	1.90 (1.14, 3.17)	0.013	2.45 (1.34, 4.47)	0.004
OASIS							0.785
≤37	468	1	2.50 (1.61, 3.90)	<0.001	3.43 (2.06, 5.71)	<0.001
>37	423	1	2.18 (1.41, 3.35)	<0.001	2.96 (1.89, 4.64)	<0.001
SOFA							0.978
≤ 7	491	1	2.68 (1.73, 4.14)	<0.001	3.81 (2.34, 6.18)	<0.001
>7	400	1	2.24 (1.45, 3.47)	<0.001	3.16 (2.00, 4.99)	<0.001
SAPS II							0.303
≤ 47	464	1	3.46 (2.10, 5.71)	<0.001	5.14 (2.95, 8.97)	<0.001
>47	427	1	1.75 (1.19, 2.59)	0.005	2.34 (1.55, 3.52)	<0.001
Oxygen therapy							0.852
No	221	1	2.24 (1.20, 4.17)	0.011	3.39 (1.58, 7.31)	0.002
Yes	670	1	2.59 (1.82, 3.70)	<0.001	3.65 (2.51, 5.29)	<0.001
PCI							0.413
No	389	1	2.97 (2.10, 4.21)	<0.001	4.47 (3.08, 6.48)	<0.001
Yes	502	1	1.43 (0.74, 2.74)	0.288	2.17 (1.08, 4.38)	0.030
RRT							0.131
No	716	1	3.00 (2.08, 4.34)	<0.001	4.84 (3.27, 7.16)	<0.001
Yes	175	1	1.70 (0.97, 2.97)	0.062	1.84 (0.99, 3.41)	0.054
Inotrope							0.164
No	539	1	2.13 (1.47, 3.09)	<0.001	3.05 (2.02, 4.60)	<0.001
Yes	352	1	3.57 (2.06, 6.16)	<0.001	5.34 (3.02, 9.44)	<0.001
Vasoconstrictor							0.485
No	240	1	2.05 (1.17, 3.62)	0.013	2.58 (1.34, 4.97)	0.005
Yes	651	1	2.78 (1.92, 4.02)	<0.001	4.13 (2.80, 6.11)	<0.001

Abbreviation: NPAR: neutrophil percentage-albumin ratio; HR: hazard ratio; CI: confidence interval; BMI: body mass index; AMI: acute myocardial infarction; AHF: acute heart failure; CHF: chronic heart failure; AF: atrial fibrillation; CAD: coronary artery disease; DM: diabetes mellitus; CKD: chronic kidney disease; OASIS: Oxford Acute Severity of Illness Score; SOFA: Sequential Organ Failure Assessment; SAPS: Simplified Acute Physiology Score; PCI: percutaneous coronary intervention; RRT: renal replacement treatment.