| | Feature | Cases | Controls | | | | % | | % |
| | Age | | Mean | 59,41 (24-92) | ±15.6 | 57,91 (20-88) | ±14.92 | | Sex | | Women | 46 | 54,12% | 89 | 53,61% | | Men | 39 | 45,88% | 77 | 46,39% | | Melanoma subtype | | Superficial spread | 20 | 23,53% | — | — | | Nodular | 13 | 15,29% | — | — | | Acral lentiginous | 21 | 24,71% | — | — | | Lentigo maligna | 31 | 36,47% | — | — | | Variant | | p.R24P | | | | | | Presence | 3 | 3,52% | 4 | 2,40% | | Absence | 82 | 93,78% | 162 | 97,60% | | p.M53i | | | | | | Presence | 0 | 0 | 0 | 0 | | Absence | 85 | 100% | 166 | 100% | | p.G101W | | | | | | Presence | 2 | 2,35% | 0 | 0 | | Absence | 83 | 97,65% | 166 | 100% | | p.V126D | | | | | | Presence | 2 | 2,35% | 2 | 1,20% | | Absence | 83 | 97,65% | 164 | 98,80% | | p.A148T | | | | | | Presence | 5 | 5,88% | 8 | 4,82% | | Absence | 80 | 94,12% | 158 | 95,18% | | Clark level | | Negative | 33 | 38,82% | — | — | | I | 2 | 2,355 | — | — | | II | 8 | 9,41% | — | — | | III | 2 | 2,35% | — | — | | IV | 35 | 41,18% | — | — | | V | 5 | 5,88% | — | — | | Breslow scale | | Nonreported | 32 | 37,65% | — | — | | ≤1,0 mm | 11 | 12,94% | — | — | | >1,0-2,0 mm | 9 | 10,59% | — | — | | >2,0-4,0 mm | 12 | 14,12% | — | — | | >4,0 mm | 21 | 24,71% | — | — | | Mitoses | | Nonreported | 32 | 37,65% | — | — | | Negative | 9 | 10,59% | — | — | | ≤1,0 mm2 | 17 | 20% | — | — | | >1,0 mm2 | 27 | 31,76% | — | — | | Ulceration | | Nonreported | 32 | 37,65% | — | — | | Presence | 18 | 21,18% | — | — | | Absence | 35 | 41,18% | — | — | | Location | | Trunk | 12 | 14,12% | — | — | | Head and neck | 37 | 43,53% | — | — | | Upper extremities | 5 | 5,88% | — | — | | Lower extremities | 9 | 10,59% | — | — | | Hands and feet | 21 | 24,70% | — | — | | Phototype | | 2 | 16 | 18,82% | 31 | 18,79% | | 3 | 59 | 69,41% | 117 | 70,91% | | 4 | 10 | 11,76% | 17 | 10,30% | | Eye color | | Black or dark brown | 44 | 51,76% | 123 | 74,10% | | Light brown | 30 | 35,29% | 27 | 16,27% | | Green | 9 | 10,59% | 9 | 5,42% | | Blue | 2 | 2,35% | 7 | 4,22% | | Hair color | | Black or dark brown | 55 | 64,71% | 136 | 81,93% | | Light brown | 29 | 34,12 | 28 | 16,87% | | Red or blond | 1 | 1,18% | 2 | 1,20% | | Personal history of cancer | | Yes | 3 | 3,52% | 9 | 5,42% | | No | 82 | 96,48% | 157 | 94,58% | | Family history of cancer | | Yes | 48 | 56,47% | 78 | 46,99% | | No | 37 | 43,53% | 88 | 53,01% | | Personal history of melanoma | | Si | 6 | 7,05% | 0 | — | | No | 79 | 92,95% | 166 | 100% | | Family history of melanoma | | Si | 7 | 8,24% | 2 | 1,20% | | No | 78 | 91,76% | 164 | 98,80% | | Nevus | | ≤50 | 71 | 83,53% | 161 | 96,99% | | 50-100 | 11 | 12,94% | 5 | 3,01% | | >100 | 3 | 3,53% | 0 | 0% |
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