Prediction of the Impact of Deleterious Nonsynonymous Single Nucleotide Polymorphisms on the Human RRM2B Gene: A Molecular Modeling Study

Table 1

Software prediction and scores for the 19 deleterious nsSNP of the RRM2B gene. For most prediction software: D: deleterious. Mutation Assessor: H: high. Mutation Taster: D: disease causing and A: disease causing automatic.

dbSNP ID

SNP

SIFT

POLYPHENE

LRT

M-CAP

PhD-SNP

SNAP

Mutation Assessor

Mutation taster

PROVEAN

Condel

PredictSNP

MAPP

PANTHER

rs515726181

R41W

D (0)

D (0.999)

D

D

D (0.875)

D (0.805)

H

D

D

D (0.935)

D (0.869)

D (0.426)

D (0.780)

rs200273673

R41P

D (0)

D (0.997)

D

D

D (0.885)

D (0.848)

H

D

D

D (0.911)

D (0.869)

D (0.560)

D (0.718)

rs267607025

R110P

D (0)

D (0.992)

D

D

D (0.858)

D (0.622)

H

D

D

D (0.892)

D (0.869)

D (0.588)

D (0.718)

rs515726187

F123S

D (0)

D (1)

D

D

D (0.817)

D (0.622)

H

D

D

D (0.945)

D (0.869)

D (0.409)

D (0.714)

rs1211197364

Y124C

D (0)

D (1)

D

D

D (0.858)

D (0.805)

H

D

D

D (0.945)

D (0.869)

D (0.588)

—

rs1185904532

E131A

D (0)

D (1)

D

D

D (0.875)

D (0.848)

H

D

D

D (0.945)

D (0.869)

D (0.633)

D (0.661)

rs515726188

E131K

D (0,01)

D (0.999)

D

D

D (0.885)

D (0.848)

H

D

D

D (0.896)

D (0.869)

D (0.483)

D (0.483)

rs1313813193

S139R

D (0)

D (1)

D

D

D (0.858)

D (0.848)

H

D

D

D (0.945)

D (0.869)

D (0.571)

—

rs1169870960

I142T

D (0,02)

D (0.992)

D

D

D (0.608)

D (0.555)

H

D

D

D (0.831)

D (0.869)

D (0.657)

D (0.661)

rs515726190

R186G

D (0)

D (0.997)

D

D

D (0.875)

D (0.720)

H

D

D

D (0.911)

D (0.869)

D (0.573)

—

rs515726191

E194G

D (0)

D (0.994)

D

D

D (0.817)

D (0.805)

H

D

D

D (0.897)

D (0.869)

D (0.571)

—

rs121918308

E194K

D (0)

D (0.996)

D

D

D (0.875)

D (0.848)

H

A

D

D (0.906)

D (0.869)

D (0.462)

—

rs515726192

G195R

D (0,02)

D (0.998)

D

D

D (0.875)

D (0.805)

H

D

D

D (0.857)

D (0.869)

D (0.633)

D (0.742)

rs863224192

G200E

D (0)

D (0.998)

D

D

D (0.885)

D (0.848)

H

D

D

D (0.919)

D (0.869)

D (0.877)

—

rs1283028277

F206V

D (0)

D (0.912)

D

D

D (0.817)

D (0.6221)

H

D

D

D (0.808)

D (0.869)

D (0.462)

D (0.687)

rs575109470

G216R

D (0)

D (1)

D

D

D (0.885)

D (0.720)

H

D

D

D (0.945)

D (0.869)

D (0.761)

—

rs1422185855

D227V

D (0)

D (1)

D

D

D (0.875)

D (0.805)

H

D

D

D (0.945)

D (0.869)

D (0.775)

—

rs772868983

H231Q

D (0)

D (0.998)

D

D

D (0.858)

D (0.848)

H

D

D

D (0.919)

D (0.869)

D (0.509)

D (0.687)

rs1215473912

A235T

D (0)

D (0.96)

D

D

D (0.676)

D (0.555)

H

D

D

D (0.848)

D (0.869)

D (0.633)

D (0.611)