Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2

<div>Fluvastatin pretreatment adjust migration ability of donor derived cells. (a) Total mononuclear cell number. (b) Flow cytometric analysis of CD3<sup>+</sup> T cell proportion and (c) absolute number of CD3<sup>+</sup> T cells in thymus, spleen, lymph nodes, and blood from recipients receiving Fluvastatin-pretreated or Fluvastatin-unpretreated donor cells. (d) Infiltration of CD3<sup>+</sup> T cells in GVHD target organs were measured (cell number/section) by immunohistochemical staining on days 3, 7, 14, 21, and 28 (e) posttransplantation. Slices of target organs were shown (×200). 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BioMed Research International

fig3

Figure 3

Figure 3: Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2 

Figure 3 | Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2 