Research Article
Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2
Figure 4
The expression of molecules related to T cell migration after Fluvastatin treatment in vivo. C57BL/6 mice were intraperitoneally injected with Fluvastatin or an equal volume of buffer daily for 7 consecutive days before sacrificed. The expression of (a) CD62L, (b) CCR7, (c) S1P1, (d) CD44, and (e) CXCR3 on spleen and bone marrow T cells were detected by flow cytometry. (f) The proportion of CD3+ T cells in the spleen and bone marrow from buffer- and Fluvastatin-treated mice were explored by flow cytometry. Data represents the of results from 3 experiments ( per group). , , n.s .
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