Sulfonamide-Based Azaheterocyclic Schiff Base Derivatives as Potential Carbonic Anhydrase Inhibitors: Synthesis, Cytotoxicity, and Enzyme Inhibitory Kinetics

<div>Lineweaver–Burk plots for inhibition of carbonic anhydrase with derivative <b>3c</b>. (a) Concentrations of <b>3c</b> were 0.00, 7.1, 14.2, and 28.4 <i>μ</i>M, respectively. Substrate <i>p</i>-nitrophenyl acetate concentrations were 0.0625, 0.125, 0.25, 0.5, 1, and 2 mM. (b) The inset shows the plot of the slope versus <b>3c</b> concentrations to find the inhibition constant. Lines were drawn by linear least squares fit.</div>

BioMed Research International

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Figure 1: Sulfonamide-Based Azaheterocyclic Schiff Base Derivatives as Potential Carbonic Anhydrase Inhibitors: Synthesis, Cytotoxicity, and Enzyme Inhibitory Kinetics 

Figure 1 | Sulfonamide-Based Azaheterocyclic Schiff Base Derivatives as Potential Carbonic Anhydrase Inhibitors: Synthesis, Cytotoxicity, and Enzyme Inhibitory Kinetics 