Lipopolysaccharide Inhibits Alpha Epithelial Sodium Channel Expression via MiR-124-5p in Alveolar Type 2  Epithelial Cells

Figure 7

Potential mechanisms for miR-124-5p involved in LPS-induced lung epithelial injury cell model. The level of miR-124-5p increases during LPS-induced ALI, which can bind 3′-UTR of α-ENaC and decrease its expression and function in alveolar epithelial cells, leading to the occurrence of pulmonary edema. ALI: acute lung injury; ENaC: epithelial sodium channel; ΑΤ1: alveolar type 1 epithelial cells; ΑΤ2: alveolar type 2 epithelial cells.