Association of Toll-Like Receptor 4 Gene Polymorphisms with Acute Aortic Dissection in a Chinese Han Population
Table 3
Association of TLR4 polymorphisms with the risk of AAD stratified by age and sex.
Genotypes
Control
AAD
OR (95% CI)
rs10759932
Age
>55y
TT
50 (42.4%)
61 (52.1%)
TC
46 (39.0%)
45 (38.5%)
0.464
0.786 (0.413-1.497)
CC
22 (8.6%)
11 (9.4%)
0.075
0.418 (0.160-1.093)
CC+TC vs. TT
0.153
0.644 (0.353-1.177)
CC vs. TC+TT
0.097
0.472 (0.195-1.144)
≤55y
TT
43 (41.3%)
45 (44.1%)
TC
49 (47.1%)
49 (48.0%)
0.598
0.787 (0.323-1.917)
CC
12 (11.5%)
8 (7.8%)
0.240
0.275 (0.032-2.371)
CC+TC vs. TT
0.482
0.731 (0.306-1.749)
CC vs. TC+TT
0.315
0.355 (0.047-2.682)
Sex
Male
TT
66 (40.5%)
67 (41.4%)
TC
70 (42.9%)
83 (51.2%)
0.560
1.198 (0.652-2.198)
CC
27 (16.6%)
12 (7.4%)
0.061
0.373 (0.133-1.049)
CC+TC vs. TT
0.935
0.976 (0.549-1.737)
CC vs. TC+TT
0.026 (0.052)
0.343 (0.133-0.882)
Female
TT
27 (45.7%)
39 (68.4%)
TC
25 (42.4%)
11 (19.3%)
0.015 (0.030)
0.231 (0.071-0.752)
CC
7 (11.9%)
7 (12.3%)
0.253
0.365 (0.065-2.054)
CC+TC vs. TT
0.010 (0.020)
0.241 (0.082-0.707)
CC vs. TC+TT
0.480
0.550 (0.105-2.890)
rs11536889
Age
>55y
GG
83 (70.9%)
78 (66.7%)
GC
30 (25.6%)
29 (24.8%)
0.935
1.029 (0.518-2.044)
CC
4 (3.4%)
10 (8.5%)
0.436
1.807 (0.408-8.009)
CC+GC vs. GG
0.702
1.134 (0.596-2.159)
CC vs. GC+GG
0.423
1.831 (0.417-8.031)
≤55y
GG
71 (69.6%)
70 (66.7%)
GC
27 (26.5%)
29 (27.6%)
0.907
1.064 (0.379-2.983)
CC
4 (3.9%)
6 (5.7%)
0.962
1.055 (0.116-9.595)
CC+GC vs. GG
0.941
0.965 (0.367-2.532)
CC vs. GC+GG
0.848
1.226 (0.153-9.824)
Sex
Male
GG
114 (71.3%)
115 (70.1%)
GC
41 (25.6%)
40 (24.4%)
0.384
0.746 (0.386-1.442)
CC
5 (3.1%)
9 (5.5%)
0.585
1.469 (0.369-5.839)
CC+GC vs. GG
0.534
0.822 (0.444-1.524)
CC vs. GC+GG
0.482
1.630 (0.418-6.360)
Female
GG
40 (67.8%)
33 (56.9%)
GC
16 (27.1%)
18 (31.0%)
0.041 (0.082)
3.382 (1.051-10.885)
CC
3 (5.1%)
7 (12.1%)
0.590
1.729 (0.236-12.673)
CC+GC vs. GG
0.042 (0.084)
3.043 (1.041-8.900)
CC vs. GC+GG
0.786
1.313 (0.183-9.437)
for association was adjusted by obesity, smoking, drinking, hypertension, diabetes, and dyslipidemia. : values after Bonferroni correction. The results are in bold if .
