BioMed Research International

Research Article

Association of Toll-Like Receptor 4 Gene Polymorphisms with Acute Aortic Dissection in a Chinese Han Population

Table 4

The interaction effects between TLR4 polymorphisms and risk factors in the susceptibility to AAD.


SNP genotypes	Number of subjects	Obesity^a		Smoking^b		Drinking^c	Hypertension^d		Dyslipidemia^e
SNP genotypes	Number of subjects	No	Yes	No	Yes	No	Yes	No	Yes	No	Yes
rs10759932
CC+TC	No. of controls/cases	99/75	28/27	59/73	49/36	69/83	39/26	72/17	57/96	69/50	60/61
CC+TC	OR (95% CI)	1.0 (ref.)	1.234 (0.651-2.337)	1.0 (ref.)	0.564 (0.319-0.997)	1.0 (ref.)	0.497 (0.268-0.922)	1.0 (ref.)	7.250 (3.662-14.353)	1.0 (ref.)	1.433 (0.825-2.488)
TT	No. of controls/cases	74/69	14/26	53/69	32/35	53/71	32/33	57/29	36/77	52/57	40/43
	No. of controls/cases	1.035 (0.646-1.659)	1.952 (0.940-4.056)	0.954 (0.563-1.616)	0.837 (0.456-1.537)	1.065 (0.643-1.764)	0.716 (0.388-1.322)	1.657 (0.745-3.687)	7.812 (3.829-15.940)	1.360 (0.769-2.405)	1.377 (0.748-2.533)
	OR (95% CI)	1.035 (0.646-1.659)	1.952 (0.940-4.056)	0.954 (0.563-1.616)	0.837 (0.456-1.537)	1.065 (0.643-1.764)	0.716 (0.388-1.322)	1.657 (0.745-3.687)	7.812 (3.829-15.940)	1.360 (0.769-2.405)	1.377 (0.748-2.533)
	OR (95% CI)	, (0.377-3.830)		, (0.624-4.546)		, (0.376-3.035)	, (0.267-2.105)		, (0.263-1.798)
CC	No. of controls/cases	24/12	10/4	16/11	12/8	19/13	9/6	20/2	14/17	20/8	14/11
CC	OR (95% CI)	1.0 (ref.)	0.768 (0.191-3.089)	1.0 (ref.)	0.889 (0.248-3.183)	1.0 (ref.)	0.768 (0.191-3.089)	1.0 (ref.)	10.045 (1.890-53.403)	1.0 (ref.)	3.667 (0.934-14.392)
TC+TT	No. of controls/cases	149/132	32/49	96/131	69/63	103/141	62/53	109/44	79/156	101/99	86/93
	OR (95% CI)	1.620 (0.741-3.545)	2.740 (1.141-6.579)	2.197 (0.927-5.209)	1.469 (0.604-3.572)	2.213 (1.005-4.872)	1.226 (0.531-2.831)	2.965 (0.647-13.597)	16.174 (3.635-71.956)	4.047 (1.300-12.603)	4.438 (1.419-13.883)
	OR (95% CI)	, (0.320-10.550)		, (0.147-3.616)	, (0.074-2.533)				, (0.104-4.237)	, (0.047-1.428)
rs11536889
GG	No. of controls/cases	117/96	32/39	79/92	51/54	84/104	46/42	86/26	68/122	87/64	66/78
GG	OR (95% CI)	1.0 (ref.)	1.473 (0.833-2.605)	1.0 (ref.)	0.886 (0.532-1.473)	1.0 (ref.)	0.623 (0.363-1.068)	1.0 (ref.)	7.041 (3.785-13.097)	1.0 (ref.)	1.545 (0.938-2.548)
CC+GC	No. of controls/cases	53/50	10/15	33/51	28/19	38/51	23/19	41/20	24/54	33/45	32/27
	OR (95% CI)	1.049 (0.638-1.718)	1.561 (0.659-3.694)	1.333 (0.760-2.337)	0.583 (0.295-1.154)	1.061 (0.622-1.809)	0.604 (0.298-1.223)	1.618 (0.724-3.616)	7.596 (3.651-15.802)	1.500 (0.824-2.729)	1.034 (0.543-1.972)
	OR (95% CI)	, (0.305-4.069)		, (0.118-1.011)	, (0.172-1.646)	, (0.245-2.078)				, (0.146-1.166)
GC+GG	No. of controls/cases	164/136	41/51	106/134	78/67	116/143	68/58	124/42	87/164	113/101	97/97
GC+GG	OR (95% CI)	1.0 (ref.)	1.463 (0.895-2.393)	1.0 (ref.)	0.664 (0.431-1.022)	1.0 (ref.)	0.603 (0.384-0.948)	1.0 (ref.)	5.873 (3.603-9.572)	1.0 (ref.)	1.071 (0.714-1.605)
CC	No. of controls/cases	6/10	1/3	6/9	1/6	6/12	1/3	3/4	5/12	7/8	1/8
	OR (95% CI)	1.805 (0.575-5.660)	3.384 (0.348-32.950)	1.053 (0.312-3.554)	4.386 (0.504-38.175)	1.571 (0.511-4.829)	1.746 (0.156-19.519)	1.613 (0.141-18.395)	8.065 (2.363-27.523)	1.143 (0.371-3.524)	7.838 (0.962-63.858)
	OR (95% CI)	, (0.066-15.184)		, (0.456-86.754)	, (0.136-53.671)	, (0.076-21.291)				(0.076^#), (1.156-200.621)

^a for association was adjusted by age, sex, smoking, drinking, hypertension, diabetes, and dyslipidemia. ^b for association was adjusted by age, sex, obesity, drinking, hypertension, diabetes, and dyslipidemia. ^c for association was adjusted by age, sex, obesity, smoking, hypertension, diabetes, and dyslipidemia. ^d for association was adjusted by age, sex, obesity, smoking, drinking, diabetes, and dyslipidemia. ^e for association was adjusted by age, sex, obesity, smoking, drinking, hypertension, and diabetes. ^# value after Bonferroni correction. The results are in bold if .