Connective Tissue Growth Factor in Digestive System Cancers: A Review and Meta-Analysis

Table 3

Meta-analysis of the pooled HRs of OS and DFS of different types of cancer with elevated CTGF expression.

Categories	Studies	Number of patients	HR (95% CI)	value	Heterogeneity
					(%)
OS	9	1301	1.05 (0.50, 2.23)	0.89	89%	<0.0001
HCC	2	462	3.60 (1.90, 6.81)	<0.0001	0%	0.95
GC	2	267	1.69 (1.12, 2.55)	0.01	0%	0.80
CRC	2	255	0.17 (0.09, 0.33)	<0.0001	0%	0.49
DFS	7	1127	0.84 (0.37, 1.88)	0.67	87%	<0.0001
HCC	3	444	1.90 (1.38, 2.62)	<0.0001	0%	0.68
Non-HCC	3	310	0.26 (0.16, 0.43)	<0.0001	45%	0.16